Gout
About:
This article is published in BMJ.The article was published on 2011-04-01 and is currently open access. It has received 729 citations till now.read more
Citations
More filters
Journal ArticleDOI
Effects of RuPeng15 Powder (RPP15) on Monosodium Urate Crystal-Induced Gouty Arthritis in Rats
TL;DR: It is concluded that RPP15 may be a promising candidate for the development of a new treatment for gout and its activity of antigout may be partially related to inhibiting TNF-α, IL-1β,IL-8, and NF-κB p65 expression in the synovial tissues.
Journal ArticleDOI
Genomic Influences on Hyperuricemia and Gout.
TL;DR: Three GWAS loci contain uric acid transporter genes, which are highly likely to be causal and results in internalization of ABCG2, which can be rescued by drugs, but identification of causal genes at other urate loci is challenging.
Journal ArticleDOI
Oral Treatment With an Engineered Uricase, ALLN-346, Reduces Hyperuricemia, and Uricosuria in Urate Oxidase-Deficient Mice.
Kateryna Pierzynowska,Aditi R. Deshpande,Nadiia Mosiichuk,Robert Terkeltaub,Paulina Szczurek,Eduardo Salido,Stefan Pierzynowski,Danica Grujic +7 more
TL;DR: Oral enzyme therapy with engineered urate oxidase (ALLN-346) designed to degrade urate in the intestinal tract has the potential to reduce hyperuricemia and the renal burden of filtered urates in patients with hyperuricaemia and gout with and without CKD.
Journal ArticleDOI
Some historical remarks on microcrystalline arthritis (gout and chondrocalcinosis).
P. Marson,Giampiero Pasero +1 more
TL;DR: Another form of microcrystalline arthritis, chondrocalcinosis, was identified as being a rheumatic disorder different from gout in the 1960s, and was first identified in 1958 by Dušan Žitnˇan and Štefan Sit'aj in a few Slovak families.
Journal ArticleDOI
Colchicinoids from Colchicum crocifolium Boiss. (Colchicaceae)
Feras Q. Alali,Ahmad A. Gharaibeh,Abdullah Ghawanmeh,Khaled Tawaha,Amjad M. Qandil,Jason P. Burgess,Arlene Sy,Yuka Nakanishi,David J. Kroll,Nicholas H. Oberlies +9 more
TL;DR: A new colchicinoid from Colchicum crocifolium Boiss was isolated and identified as N,N-dimethyl-N-deacetyl-(−)-cornigerine, along with four known compounds, but new to the species.
References
More filters
Book
The Metabolic and Molecular Bases of Inherited Disease
TL;DR: In this paper, the authors present a list of disorders of MITOCHONDRIAL FUNCTION, including the following: DISORDERS OF MIOCHONDRIC FERTILITY XIX, XVI, XIX.
Journal ArticleDOI
2007 Guidelines for the Management of Arterial Hypertension : The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC).
Giuseppe Mancia,Guy De Backer,Anna F. Dominiczak,Renata Cifkova,Robert Fagard,Giuseppe Germanò,Guido Grassi,Anthony M. Heagerty,Sverre E. Kjeldsen,Stéphane Laurent,Krzysztof Narkiewicz,Luis M. Ruilope,Andrzej Rynkiewicz,Roland E. Schmieder,Harry A.J. Struijker Boudier,Alberto Zanchetti +15 more
TL;DR: 2007 Guidelines for the Management of Arterial Hypertension : The Task Force for the management of Arterspertension of the European Society ofhypertension (ESH) and of theEuropean Society of Cardiology (ESC).
Book
A Laboratory manual
TL;DR: To develop a program to print the barcodes using two commonly uses command sets and hence evaluates their ease of use for such applications, students should be able to program dot matrix printers, by manipulating bit level information and ink jet printers using page description language, such as PCL.