Gout
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This article is published in BMJ.The article was published on 2011-04-01 and is currently open access. It has received 729 citations till now.read more
Citations
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2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia
Dinesh Khanna,John FitzGerald,Puja P. Khanna,Sangmee Bae,Manjit K. Singh,Tuhina Neogi,Michael H. Pillinger,Joan Merill,Susan J. Lee,Shraddha Prakash,Marian Kaldas,Maneesh Gogia,Fernando Perez-Ruiz,William J. Taylor,Frédéric Lioté,Hyon K. Choi,Jasvinder A. Singh,Nicola Dalbeth,Sanford Kaplan,Vandana Dua Niyyar,Danielle Jones,Steven A. Yarows,Blake J. Roessler,Gail S. Kerr,Charles H. King,Gerald Levy,Daniel E. Furst,N. Lawrence Edwards,Brian F. Mandell,H. Ralph Schumacher,Mark L. Robbins,Neil S. Wenger,Robert Terkeltaub +32 more
TL;DR: DINESH KHanNA, JOHN D. FITZGERALD, PUJA P. KHANNA, SANGMEE BAE, MANJIT K. SINGH, TUHINA NEOGI, MICHAEL H. PILLINGER, JOAN MERILL, SUSAN LEE, SHRADDHA PRAKASH, MARIAN KALDAS, MANEESH GOGIA, FERNANDO PEREZ-RUI
Journal ArticleDOI
Sugar-sweetened beverages and risk of obesity and type 2 diabetes: Epidemiologic evidence
Frank B. Hu,Vasanti S. Malik +1 more
TL;DR: It is thought that SSBs contribute to weight gain in part by incomplete compensation for energy at subsequent meals following intake of liquid calories, and should be replaced by healthy alternatives such as water, to reduce risk of obesity and chronic diseases.
Journal ArticleDOI
Uric acid transport and disease.
Alexander So,Bernard Thorens +1 more
TL;DR: The biology of urate metabolism and its role in disease is discussed and recent studies identifying SLC2A9, which encodes the glucose transporter family isoform Glut9, as a major determinant of plasma uric acid levels and of gout development are identified.
Journal ArticleDOI
A Broader View: Microbial Enzymes and Their Relevance in Industries, Medicine, and Beyond
TL;DR: In this review, an approach has been made to highlight the importance of different enzymes with special emphasis on amylase and lipase in the different industrial and medical fields.
Journal ArticleDOI
Where is mTOR and what is it doing there
Charles Betz,Michael N. Hall +1 more
TL;DR: The finding that mTORC1 is localized to the lysosome has significantly enhanced the understanding of m TORC1 regulation and may be a general principle used by TOR to enact precise spatial and temporal control of cell growth.
References
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Journal ArticleDOI
Prevention and treatment of the metabolic syndrome.
TL;DR: Among the more speculative benefits of treatment are improved liver function in nonalcoholic fatty liver disease and a reduction in the risk of acute gout and drugs that beneficially affect carbohydrate metabolism and delay or even prevent the onset of DM could be useful in patients with the metabolic syndrome.
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Allopurinol Dosing in Renal Impairment: Walking the Tightrope Between Adequate Urate Lowering and Adverse Events
Nicola Dalbeth,Lisa K. Stamp +1 more
TL;DR: In patients with severe disease and persistent hyperuricemia, allopurinol dose escalation above those recommended by the guidelines should be considered, with careful evaluation of the benefits and risks of therapy.
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Uricosuric Action of Losartan via the Inhibition of Urate Transporter 1 (URAT 1) in Hypertensive Patients
Toshihiro Hamada,Kimiyoshi Ichida,Makoto Hosoyamada,Einosuke Mizuta,Kiyotaka Yanagihara,Kazuhiko Sonoyama,Shinobu Sugihara,Osamu Igawa,Tatsuo Hosoya,Akira Ohtahara,Chiaki Shigamasa,Yasutaka Yamamoto,Haruaki Ninomiya,Ichiro Hisatome +13 more
TL;DR: It is suggested thatLosartan inhibited URAT1 and thereby it lowered Sur levels in hypertensive patients, and both losartan and benzbromarone increased Cur/Ccr ratio in hypertension patients harboring the wild URAT 1 gene, regardless of the presence of hypouricemia.
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Pharmacokinetics and pharmacodynamics of febuxostat, a new non-purine selective inhibitor of xanthine oxidase in subjects with renal impairment.
Michael D. Mayer,Reza Khosravan,Laurent Vernillet,Jingtao Wu,Nancy Joseph-Ridge,Darcy Mulford +5 more
TL;DR: A once-daily 80-mg dose of febuxostat appears to be safe and well tolerated in different renal function groups and does not appear to require any dose adjustment based on differences in renal function.
Journal ArticleDOI
The genetic basis of hyperuricaemia and gout.
Tony R. Merriman,Nicola Dalbeth +1 more
TL;DR: Genome-wide association scans for genes regulating serum urate concentrations have identified two major regulators of hyperuricaemia- the renal urate transporters SLC2A9 and ABCG2 and risk variants at each gene approximately double the risk for gout in people of Caucasian ancestry.