Gout
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This article is published in BMJ.The article was published on 2011-04-01 and is currently open access. It has received 729 citations till now.read more
Citations
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2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia
Dinesh Khanna,John FitzGerald,Puja P. Khanna,Sangmee Bae,Manjit K. Singh,Tuhina Neogi,Michael H. Pillinger,Joan Merill,Susan J. Lee,Shraddha Prakash,Marian Kaldas,Maneesh Gogia,Fernando Perez-Ruiz,William J. Taylor,Frédéric Lioté,Hyon K. Choi,Jasvinder A. Singh,Nicola Dalbeth,Sanford Kaplan,Vandana Dua Niyyar,Danielle Jones,Steven A. Yarows,Blake J. Roessler,Gail S. Kerr,Charles H. King,Gerald Levy,Daniel E. Furst,N. Lawrence Edwards,Brian F. Mandell,H. Ralph Schumacher,Mark L. Robbins,Neil S. Wenger,Robert Terkeltaub +32 more
TL;DR: DINESH KHanNA, JOHN D. FITZGERALD, PUJA P. KHANNA, SANGMEE BAE, MANJIT K. SINGH, TUHINA NEOGI, MICHAEL H. PILLINGER, JOAN MERILL, SUSAN LEE, SHRADDHA PRAKASH, MARIAN KALDAS, MANEESH GOGIA, FERNANDO PEREZ-RUI
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Sugar-sweetened beverages and risk of obesity and type 2 diabetes: Epidemiologic evidence
Frank B. Hu,Vasanti S. Malik +1 more
TL;DR: It is thought that SSBs contribute to weight gain in part by incomplete compensation for energy at subsequent meals following intake of liquid calories, and should be replaced by healthy alternatives such as water, to reduce risk of obesity and chronic diseases.
Journal ArticleDOI
Uric acid transport and disease.
Alexander So,Bernard Thorens +1 more
TL;DR: The biology of urate metabolism and its role in disease is discussed and recent studies identifying SLC2A9, which encodes the glucose transporter family isoform Glut9, as a major determinant of plasma uric acid levels and of gout development are identified.
Journal ArticleDOI
A Broader View: Microbial Enzymes and Their Relevance in Industries, Medicine, and Beyond
TL;DR: In this review, an approach has been made to highlight the importance of different enzymes with special emphasis on amylase and lipase in the different industrial and medical fields.
Journal ArticleDOI
Where is mTOR and what is it doing there
Charles Betz,Michael N. Hall +1 more
TL;DR: The finding that mTORC1 is localized to the lysosome has significantly enhanced the understanding of m TORC1 regulation and may be a general principle used by TOR to enact precise spatial and temporal control of cell growth.
References
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Polyarticular versus monoarticular gout: a prospective, comparative analysis of clinical features.
TL;DR: No single laboratory or synovial fluid value meaningfully distinguishes patients with polyarticular from those with monoarticular gout, reflecting chronicity associated with poor patients understanding, poor patient compliance, and suboptimal physician management.
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Diagnosis of Chronic Gout: Evaluating the American College of Rheumatology Proposal, European League Against Rheumatism Recommendations, and Clinical Judgment
Ingris Peláez-Ballestas,Claudia Berenice Hernández Cuevas,Rubén Burgos-Vargas,Lizandra Hernández Roque,Leobardo Terán,Jesús Espinoza,Jorge A. Esquivel-Valerio,María Victoria Goycochea-Robles,Francisco J. Aceves,Ana Guilaisne Bernard,Lucio Ventura,Clara Shumsky,Adolfo Hernández Garduño,Janitzia Vázquez-Mellado +13 more
TL;DR: Current or past history of ≥ 4/8 CGD parameters is highly suggestive of chronic gout, and clinical and paraclinical data included in the European League Against Rheumatism and American College of Rheumatology proposed criteria for diagnosis of gout are identified.
Journal ArticleDOI
Current principles of management in gout
Alexander B. Gutman,Tsʾai-Fan Yü +1 more
TL;DR: Experience with forty gouty subjects given daily dosage for six months to two years indicates that formation of new tophi and enlargement of old tophi can be prevented.
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A common mutation in an organic anion transporter gene, SLC22A12, is a suppressing factor for the development of gout.
Atsuo Taniguchi,Wako Urano,Mariko Yamanaka,Hisashi Yamanaka,Makoto Hosoyamada,Hitoshi Endou,Naoyuki Kamatani +6 more
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Effect of Micronized Fenofibrate and Losartan Combination on Uric Acid Metabolism in Hypertensive Patients with Hyperuricemia
TL;DR: It is concluded that the combination of micronized fenofibrate and losartan is useful for the management of patients with multiple metabolic abnormalities, including hyperuricemia.