Gout
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This article is published in BMJ.The article was published on 2011-04-01 and is currently open access. It has received 729 citations till now.read more
Citations
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2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia
Dinesh Khanna,John FitzGerald,Puja P. Khanna,Sangmee Bae,Manjit K. Singh,Tuhina Neogi,Michael H. Pillinger,Joan Merill,Susan J. Lee,Shraddha Prakash,Marian Kaldas,Maneesh Gogia,Fernando Perez-Ruiz,William J. Taylor,Frédéric Lioté,Hyon K. Choi,Jasvinder A. Singh,Nicola Dalbeth,Sanford Kaplan,Vandana Dua Niyyar,Danielle Jones,Steven A. Yarows,Blake J. Roessler,Gail S. Kerr,Charles H. King,Gerald Levy,Daniel E. Furst,N. Lawrence Edwards,Brian F. Mandell,H. Ralph Schumacher,Mark L. Robbins,Neil S. Wenger,Robert Terkeltaub +32 more
TL;DR: DINESH KHanNA, JOHN D. FITZGERALD, PUJA P. KHANNA, SANGMEE BAE, MANJIT K. SINGH, TUHINA NEOGI, MICHAEL H. PILLINGER, JOAN MERILL, SUSAN LEE, SHRADDHA PRAKASH, MARIAN KALDAS, MANEESH GOGIA, FERNANDO PEREZ-RUI
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Sugar-sweetened beverages and risk of obesity and type 2 diabetes: Epidemiologic evidence
Frank B. Hu,Vasanti S. Malik +1 more
TL;DR: It is thought that SSBs contribute to weight gain in part by incomplete compensation for energy at subsequent meals following intake of liquid calories, and should be replaced by healthy alternatives such as water, to reduce risk of obesity and chronic diseases.
Journal ArticleDOI
Uric acid transport and disease.
Alexander So,Bernard Thorens +1 more
TL;DR: The biology of urate metabolism and its role in disease is discussed and recent studies identifying SLC2A9, which encodes the glucose transporter family isoform Glut9, as a major determinant of plasma uric acid levels and of gout development are identified.
Journal ArticleDOI
A Broader View: Microbial Enzymes and Their Relevance in Industries, Medicine, and Beyond
TL;DR: In this review, an approach has been made to highlight the importance of different enzymes with special emphasis on amylase and lipase in the different industrial and medical fields.
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Where is mTOR and what is it doing there
Charles Betz,Michael N. Hall +1 more
TL;DR: The finding that mTORC1 is localized to the lysosome has significantly enhanced the understanding of m TORC1 regulation and may be a general principle used by TOR to enact precise spatial and temporal control of cell growth.
References
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Neutropenia and impaired neutrophil migration in type IB glycogen storage disease
Arthur L. Beaudet,Arthur L. Beaudet,Donald C. Anderson,Donald C. Anderson,Virginia V. Michels,Virginia V. Michels,William J. Arion,William J. Arion,Alex J. Lange,Alex J. Lange +9 more
TL;DR: The association of neutropenia with type IB glycogen storage disease was observed in siblings and in vitro studies of neutrophils indicated a defect in random and directed cell migration, suggesting that a role for glucose-6-phosphate transport in neutrophil should be considered.
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Treating to target: a strategy to cure gout
TL;DR: There is good evidence that achieving sUA <6 mg/dl (360 micromol/l) results in freedom from acute gout attacks, and shrinkage and eventual disappearance of tophi, so that new crystals cannot form and existing crystals are dissolved.
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The Experience and Impact of Living With Gout A Study of Men With Chronic Gout Using a Qualitative Grounded Theory Approach
TL;DR: Previously hidden perspectives of the experience of gout are provided, suggesting that shame, embarrassment, and stigma lead to trivialization of the impact of disease despite its severity, which could contribute to the development of progressive gout.
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Quality of care indicators for gout management
Ted R. Mikuls,Catherine H. MacLean,Jason J. Olivieri,Fausto G. Patino,Jeroan J. Allison,John T. Farrar,Warren B. Bilker,Kenneth G. Saag +7 more
TL;DR: Using a combination of evidence and expert opinion, 10 indicators for quality of gout care were developed and represent an important initial step in quality improvement initiatives for gout Care.
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The murine homolog of the interleukin-8 receptor CXCR-2 is essential for the occurrence of neutrophilic inflammation in the air pouch model of acute urate crystal-induced gouty synovitis.
TL;DR: Chemokines that bind the IL-8 receptor CXCR-2 are essential for the development of acute neutrophilic inflammation in response to urate crystals in the subcutaneous air pouch model.