Journal ArticleDOI
Gut microbiome and metabolic syndrome
TLDR
Modification of gut microbiota via prebiotics, probiotics or other dietary interventions has provided evidence to support a possible beneficial effect of interventions targeting gut microbiota modulation to treat components or complications of metabolic syndrome.Abstract:
The gut microbiome contributes approximately 2kg of the whole body weight, and recent studies suggest that gut microbiota has a profound effect on human metabolism, potentially contributing to several features of the metabolic syndrome. Metabolic syndrome is defined by a clustering of metabolic disorders that include central adiposity with visceral fat accumulation, dyslipidemia, insulin resistance, dysglycemia and non-optimal blood pressure levels. Metabolic syndrome is associated with an increased risk of cardiovascular diseases and type 2 diabetes. It is estimated that around 20-25 percent of the world's adult population has metabolic syndrome. In this manuscript, we have reviewed the existing data linking gut microbiome with metabolic syndrome. Existing evidence from studies both in animals and humans support a link between gut microbiome and various components of metabolic syndrome. Possible pathways include involvement with energy homeostasis and metabolic processes, modulation of inflammatory signaling pathways, interferences with the immune system, and interference with the renin-angiotensin system. Modification of gut microbiota via prebiotics, probiotics or other dietary interventions has provided evidence to support a possible beneficial effect of interventions targeting gut microbiota modulation to treat components or complications of metabolic syndrome.read more
Citations
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Dissertation
Isolation and characterization of a novel antimicrobial peptide from Bufo bufo gargarizans = 한국산 두꺼비로부터 새로운 항균 펩타이드 분리와 그 특성 연구
Chan-Bae Park,박찬배 +1 more
TL;DR: A potent and structurally novel antimicrobial peptide was isolated and characterized from the stomach tissue of Bufo bufo gargarizans, an Asian toad.
Journal ArticleDOI
The Gut Microbiota and Inflammation: An Overview.
TL;DR: The relationship between the gut microbiota and inflammatory molecules and by-products of metabolic processes in bacteria, including some short-chain fatty acids, can play a role in inhibiting inflammatory processes.
Journal ArticleDOI
Human-origin probiotic cocktail increases short-chain fatty acid production via modulation of mice and human gut microbiome
Ravinder Nagpal,Shaohua Wang,Shokouh Ahmadi,Joshua Hayes,Jason Gagliano,Sargurunathan Subashchandrabose,Dalane W. Kitzman,Thomas Becton,Russel Read,Hariom Yadav +9 more
TL;DR: Results indicate that human-origin probiotic lactobacilli and enterococci could ameliorate gut microbiome dysbiosis and hence may prove to be a potential therapy for diseases involving reduced SCFAs production in the gut.
Journal ArticleDOI
The human microbiome.
TL;DR: Novel culture-independent molecular biochemical analyses allow today to detect and classify the diverse microorganisms in a given ecosystem (microbiota), such as the gastrointestinal tract, the skin, the airway system, the urogenital tract and others, and to assess all genomes in these ecosystems as well as their gene products.
Journal ArticleDOI
Adipose tissue and insulin resistance in obese.
TL;DR: In this paper, the authors highlight the potential mechanisms behind obesity-associated insulin resistance and suggest that the liver is the most sensitive organ undergoing insulin impairment faster than other organs, and thus, hepatic insulin resistance is the primary event that leads to the subsequent development of peripheral tissue insulin resistance.
References
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