PatentDOI
Histone demethylation mediated by the nuclear amine oxidase homolog lsd1
Yang Shi,Yujiang Shi +1 more
TLDR
In this paper, the authors identify a histone demethylase conserved from S. pombe to human and reveal dynamic regulation of histone methylation by both histonemethylases and demethylases.About:
This article is published in Cell.The article was published on 2005-12-16. It has received 3281 citations till now. The article focuses on the topics: Histone lysine demethylation & Histone demethylation.read more
Citations
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Journal ArticleDOI
Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and independent manners
TL;DR: Surprisingly, whereas it is confirmed that inhibition of LSD1 strongly inhibits proliferation of breast cancer cells, it is determined that the cytostatic actions of LSD2 inhibition are not impacted by ER status, suggesting that LSD1 may be a useful therapeutic target in several types of breast cancers.
Journal ArticleDOI
Rheostat Control of Gene Expression by Metabolites
TL;DR: Increasing evidence shows that small-molecule metabolites also shape the structure of chromatin and directly regulate the transcription and translation processes, and emerge as key effectors in tweaking gene expression.
Journal ArticleDOI
Involvement of a Jumonji-C domain-containing histone demethylase in DRM2-mediated maintenance of DNA methylation.
Angélique Deleris,Maxim V. C. Greenberg,Israel Ausin,Rona Law,Guillaume Moissiard,Daniel Schubert,Steven E. Jacobsen +6 more
TL;DR: Mutations in jmj14 result in reduced DNA methylation in non‐CG contexts at targets of DRM2 (domains rearranged methyltransferase 2)‐mediated RNA‐directed DNAmethylation (RdDM), which is associated with an increase in H3K4m3.
Journal ArticleDOI
Epigenetic Etiology of Intellectual Disability
Shigeki Iwase,Nathalie G. Bérubé,Zhaolan Zhou,Nael Nadif Kasri,Elena Battaglioli,Marilyn Scandaglia,Angel Barco +6 more
TL;DR: In this paper, the role of chromatin regulators in brain development, plasticity, and gene expression has been investigated in the context of Intellectual Disability (ID) and epigenetic regulators have been linked with these disorders.
Journal ArticleDOI
Basic helix-loop-helix transcription factors and enteroendocrine cell differentiation.
TL;DR: Understanding enteroendocrine cell differentiation will become increasingly important for identifying potential future targets for common diseases such as diabetes and obesity.
References
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Journal ArticleDOI
Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
Journal ArticleDOI
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Ru Cao,Liangjun Wang,Hengbin Wang,Li Xia,Hediye Erdjument-Bromage,Paul Tempst,Richard S. Jones,Yi Zhang +7 more
TL;DR: The purification and characterization of an EED-EZH2 complex, the human counterpart of the Drosophila ESC-E(Z) complex, is reported, and it is demonstrated that the complex specifically methylates nucleosomal histone H3 at lysine 27 (H3-K27).
Journal ArticleDOI
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
TL;DR: It is shown that mammalian methyltransferases that selectively methylate histone H3 on lysine 9 (Suv39h HMTases) generate a binding site for HP1 proteins—a family of heterochromatic adaptor molecules implicated in both gene silencing and supra-nucleosomal chromatin structure.
Journal ArticleDOI
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.
Andrew J. Bannister,Philip Zegerman,Janet F. Partridge,Eric A. Miska,Jean O. Thomas,Robin C. Allshire,Tony Kouzarides +6 more
TL;DR: A stepwise model for the formation of a transcriptionally silent heterochromatin is provided: SUV39H1 places a ‘methyl marker’ on histone H3, which is then recognized by HP1 through its chromo domain, which may also explain the stable inheritance of theheterochromatic state.
Journal ArticleDOI
Regulation of chromatin structure by site-specific histone H3 methyltransferases
Stephen Rea,Frank Eisenhaber,Dónal O'Carroll,Brian D. Strahl,Zu-Wen Sun,Manfred Schmid,Susanne Opravil,Karl Mechtler,Chris P. Ponting,C D Allis,Thomas Jenuwein +10 more
TL;DR: A functional interdependence of site-specific H3 tail modifications is revealed and a dynamic mechanism for the regulation of higher-order chromatin is suggested.