PatentDOI
Histone demethylation mediated by the nuclear amine oxidase homolog lsd1
Yang Shi,Yujiang Shi +1 more
TLDR
In this paper, the authors identify a histone demethylase conserved from S. pombe to human and reveal dynamic regulation of histone methylation by both histonemethylases and demethylases.About:
This article is published in Cell.The article was published on 2005-12-16. It has received 3281 citations till now. The article focuses on the topics: Histone lysine demethylation & Histone demethylation.read more
Citations
More filters
Journal ArticleDOI
JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer
Yang Xiang,Ziqi Zhu,Gang Han,Xiaolei Ye,Bo Xu,Zhouchun Peng,Yuanjun Ma,Yi Yu,Hanqing Lin,Adele Pin Chen,Charlie D. Chen +10 more
TL;DR: JARID1B is identified as a demethylase capable of removing three methyl groups from histone H3 lysine 4 and up-regulated in prostate cancer and associates with androgen receptor and regulates its transcriptional activity.
Journal ArticleDOI
Functions of lncRNA HOTAIR in lung cancer
TL;DR: The molecular mechanisms underlying HotaIR-mediated aggressive phenotypes of lung cancer are reviewed and HOTAIR’s potential in diagnosis and treatment of lung cancers is discussed, as well as the challenges of exploiting HOTA IR for intervention of Lung cancer.
Journal ArticleDOI
MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.
Xavier Le Guezennec,Michiel Vermeulen,Arie B. Brinkman,Wieteke A. M. Hoeijmakers,Adrian Cohen,Edwin Lasonder,Hendrik G. Stunnenberg +6 more
TL;DR: Ch Chromatin immunoprecipitation experiments revealed that PRMT5 and MBD2 are recruited to CpG islands in a methylation-dependent manner in vivo and that H4R3, a substrate of PRMT, is methylated at these loci.
Journal ArticleDOI
Chromatin modifier enzymes, the histone code and cancer
Helena Santos-Rosa,Carlos Caldas +1 more
TL;DR: Several families of transcription activators and repressors that catalyse histone post-translational modifications (acetylation, methylation, phosphorylation, ubiquitination and SUMOylation) are focused on; and how these enzymatic activities might alter the correct cell proliferation program, leading to cancer.
Journal ArticleDOI
Structural and Sequence Motifs of Protein (Histone) Methylation Enzymes
TL;DR: This review describes structural aspects of methylation of histone lysine residues by two enzyme families with entirely different structural scaffolding (the SET proteins and Dot1p) andmethylation of protein arginine residue by PRMTs.
References
More filters
Journal ArticleDOI
Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
Journal ArticleDOI
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Ru Cao,Liangjun Wang,Hengbin Wang,Li Xia,Hediye Erdjument-Bromage,Paul Tempst,Richard S. Jones,Yi Zhang +7 more
TL;DR: The purification and characterization of an EED-EZH2 complex, the human counterpart of the Drosophila ESC-E(Z) complex, is reported, and it is demonstrated that the complex specifically methylates nucleosomal histone H3 at lysine 27 (H3-K27).
Journal ArticleDOI
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
TL;DR: It is shown that mammalian methyltransferases that selectively methylate histone H3 on lysine 9 (Suv39h HMTases) generate a binding site for HP1 proteins—a family of heterochromatic adaptor molecules implicated in both gene silencing and supra-nucleosomal chromatin structure.
Journal ArticleDOI
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.
Andrew J. Bannister,Philip Zegerman,Janet F. Partridge,Eric A. Miska,Jean O. Thomas,Robin C. Allshire,Tony Kouzarides +6 more
TL;DR: A stepwise model for the formation of a transcriptionally silent heterochromatin is provided: SUV39H1 places a ‘methyl marker’ on histone H3, which is then recognized by HP1 through its chromo domain, which may also explain the stable inheritance of theheterochromatic state.
Journal ArticleDOI
Regulation of chromatin structure by site-specific histone H3 methyltransferases
Stephen Rea,Frank Eisenhaber,Dónal O'Carroll,Brian D. Strahl,Zu-Wen Sun,Manfred Schmid,Susanne Opravil,Karl Mechtler,Chris P. Ponting,C D Allis,Thomas Jenuwein +10 more
TL;DR: A functional interdependence of site-specific H3 tail modifications is revealed and a dynamic mechanism for the regulation of higher-order chromatin is suggested.