PatentDOI
Histone demethylation mediated by the nuclear amine oxidase homolog lsd1
Yang Shi,Yujiang Shi +1 more
TLDR
In this paper, the authors identify a histone demethylase conserved from S. pombe to human and reveal dynamic regulation of histone methylation by both histonemethylases and demethylases.About:
This article is published in Cell.The article was published on 2005-12-16. It has received 3281 citations till now. The article focuses on the topics: Histone lysine demethylation & Histone demethylation.read more
Citations
More filters
Journal ArticleDOI
Chromatin Modifications and Their Function
TL;DR: The surface of nucleosomes is studded with a multiplicity of modifications that can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA.
Journal ArticleDOI
Regulation of chromatin by histone modifications
TL;DR: The known histone modifications are described, where they are found genomically and discussed and some of their functional consequences are discussed, concentrating mostly on transcription where the majority of characterisation has taken place.
Journal ArticleDOI
Epigenetics in Cancer
TL;DR: The current understanding of alterations in the epigenetic landscape that occur in cancer compared with normal cells, the roles of these changes in cancer initiation and progression, including the cancer stem cell model, and the potential use of this knowledge in designing more effective treatment strategies are discussed.
Journal ArticleDOI
The Emerging Hallmarks of Cancer Metabolism
TL;DR: This Perspective has organized known cancer-associated metabolic changes into six hallmarks: deregulated uptake of glucose and amino acids, use of opportunistic modes of nutrient acquisition, useof glycolysis/TCA cycle intermediates for biosynthesis and NADPH production, increased demand for nitrogen, alterations in metabolite-driven gene regulation, and metabolic interactions with the microenvironment.
Journal ArticleDOI
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
Miao-Chih Tsai,Ohad Manor,Yue Wan,Nima Mosammaparast,Jordon K. Wang,Fei Lan,Yang Shi,Eran Segal,Howard Y. Chang +8 more
TL;DR: The results suggest that lincRNAs may serve as scaffolds by providing binding surfaces to assemble select histone modification enzymes, thereby specifying the pattern of histone modifications on target genes.
References
More filters
Journal ArticleDOI
Rb targets histone H3 methylation and HP1 to promoters
Søren J. Nielsen,Robert Schneider,Uta-Maria Bauer,Andrew J. Bannister,Ashby J. Morrison,Dónal O'Carroll,Ron Firestein,Michael D. Cleary,Thomas Jenuwein,Rafael E. Herrera,Tony Kouzarides +10 more
TL;DR: It is shown that SUV39H1 and HP1 are both involved in the repressive functions of the retinoblastoma (Rb) protein, and Chromatin immunoprecipitations show that Rb is necessary to direct methylation of histone H3, and is necessary for binding of HP1 to the cyclin E promoter.
Journal ArticleDOI
Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution.
TL;DR: The expression pattern and unique domain structure of p57 suggest that this CDI may play a specialized role in cell cycle control.
Journal ArticleDOI
Methylation of H3-Lysine 79 Is Mediated by a New Family of HMTases without a SET Domain
Qin Feng,Hengbin Wang,Huck-Hui Ng,Hediye Erdjument-Bromage,Paul Tempst,Kevin Struhl,Yi Zhang +6 more
TL;DR: The studies reveal a new methylation site and define a novel family of histone lysine methyltransferase, which is found in the globular domain of H3, and found that K79 methylation level is regulated throughout the cell cycle.
Journal ArticleDOI
Histone deimination antagonizes arginine methylation
Graeme L. Cuthbert,Sylvain Daujat,Andrew W. Snowden,Hediye Erdjument-Bromage,Teruki Hagiwara,Michiyuki Yamada,Robert Schneider,Philip D. Gregory,Paul Tempst,Andrew J. Bannister,Tony Kouzarides +10 more
TL;DR: In this paper, the peptidyl arginine deiminase 4 (PADI4) specifically deiminates, in the H3 N-terminal tail, arginines R2, R8, R17, and R26.
Journal ArticleDOI
Regulation of LSD1 histone demethylase activity by its associated factors.
TL;DR: It is shown that CoREST endows LSD1 with the ability to demethylate nucleosomal substrates and that it protects LSD1 from proteasomal degradation in vivo, suggesting that hypoacetylated nucleosomes may be the preferred physiological substrate.