PatentDOI
Histone demethylation mediated by the nuclear amine oxidase homolog lsd1
Yang Shi,Yujiang Shi +1 more
TLDR
In this paper, the authors identify a histone demethylase conserved from S. pombe to human and reveal dynamic regulation of histone methylation by both histonemethylases and demethylases.About:
This article is published in Cell.The article was published on 2005-12-16. It has received 3281 citations till now. The article focuses on the topics: Histone lysine demethylation & Histone demethylation.read more
Citations
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Journal ArticleDOI
The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor
Jotin Marango,Manabu Shimoyama,Hitomi Nishio,Julia Meyer,Dong-Joon Min,Andres Sirulnik,Yolanda Martinez-Martinez,Marta Chesi,P. Leif Bergsagel,Ming-Ming Zhou,Samuel Waxman,Boris A. Leibovitch,Martin J. Walsh,Jonathan D. Licht +13 more
TL;DR: Data suggest that, by acting directly as a modifier of chromatin as well as through binding of other chromatin-modifying enzymes, MMSET influences gene expression and potentially acts as a pathogenic agent in multiple myeloma.
Journal ArticleDOI
Arabidopsis homologs of components of the SWR1 complex regulate flowering and plant development.
TL;DR: The results strongly support the presence of an SWR1C-like complex in Arabidopsis that ensures proper development, including floral repression through full activation of FLC.
Journal ArticleDOI
Pharmacogenetic Analysis of Lithium-induced Delayed Aging in Caenorhabditis elegans*
Gawain McColl,David W. Killilea,Alan Hubbard,Maithili C. Vantipalli,Simon Melov,Gordon J. Lithgow +5 more
TL;DR: A pharmacogenetic study of Li+ in the nematode Caenorhabditis elegans shows that exposure to Li+ at clinically relevant concentrations throughout adulthood increases survival during normal aging and regulates survival by modulating histone methylation and chromatin structure.
Journal ArticleDOI
Dynamic nucleosomes and gene transcription.
TL;DR: New concepts such as dynamic nucleosomes and a dynamic histone code in gene transcription are explored in Chromatin, a nucleosomal template known as chromatin that governs gene transcription.
Journal ArticleDOI
Mechanisms of DNA–protein crosslink repair
TL;DR: Loss of these pathways renders cells sensitive to DPC-inducing chemotherapeutics, and DPC repair pathways are thus attractive targets for combination cancer therapy.
References
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Journal ArticleDOI
Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
Journal ArticleDOI
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Ru Cao,Liangjun Wang,Hengbin Wang,Li Xia,Hediye Erdjument-Bromage,Paul Tempst,Richard S. Jones,Yi Zhang +7 more
TL;DR: The purification and characterization of an EED-EZH2 complex, the human counterpart of the Drosophila ESC-E(Z) complex, is reported, and it is demonstrated that the complex specifically methylates nucleosomal histone H3 at lysine 27 (H3-K27).
Journal ArticleDOI
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
TL;DR: It is shown that mammalian methyltransferases that selectively methylate histone H3 on lysine 9 (Suv39h HMTases) generate a binding site for HP1 proteins—a family of heterochromatic adaptor molecules implicated in both gene silencing and supra-nucleosomal chromatin structure.
Journal ArticleDOI
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.
Andrew J. Bannister,Philip Zegerman,Janet F. Partridge,Eric A. Miska,Jean O. Thomas,Robin C. Allshire,Tony Kouzarides +6 more
TL;DR: A stepwise model for the formation of a transcriptionally silent heterochromatin is provided: SUV39H1 places a ‘methyl marker’ on histone H3, which is then recognized by HP1 through its chromo domain, which may also explain the stable inheritance of theheterochromatic state.
Journal ArticleDOI
Regulation of chromatin structure by site-specific histone H3 methyltransferases
Stephen Rea,Frank Eisenhaber,Dónal O'Carroll,Brian D. Strahl,Zu-Wen Sun,Manfred Schmid,Susanne Opravil,Karl Mechtler,Chris P. Ponting,C D Allis,Thomas Jenuwein +10 more
TL;DR: A functional interdependence of site-specific H3 tail modifications is revealed and a dynamic mechanism for the regulation of higher-order chromatin is suggested.