PatentDOI
Histone demethylation mediated by the nuclear amine oxidase homolog lsd1
Yang Shi,Yujiang Shi +1 more
TLDR
In this paper, the authors identify a histone demethylase conserved from S. pombe to human and reveal dynamic regulation of histone methylation by both histonemethylases and demethylases.About:
This article is published in Cell.The article was published on 2005-12-16. It has received 3281 citations till now. The article focuses on the topics: Histone lysine demethylation & Histone demethylation.read more
Citations
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Journal ArticleDOI
Arginine Demethylation of G3BP1 Promotes Stress Granule Assembly
Wei-Chih Tsai,Sitaram Gayatri,Lucas C. Reineke,Gianluca Sbardella,Mark T. Bedford,Richard E. Lloyd +5 more
TL;DR: Examination of the potent SG-nucleating protein Ras-GAP SH3-binding protein 1 (G3BP1) is examined, and it is found that arginine methylation in the RGG domain prevents large SG assembly and rapid demethylation is a novel signal that regulates SG formation.
Journal ArticleDOI
Histone modifications dictate specific biological readouts.
TL;DR: This review focuses on complex modification patterns that seem to be part of a complex scheme where distinct histone modifications act in a sequential manner or in combination to form a "histone code" read by other proteins to control the structure and/or function of the chromatin fiber.
Journal ArticleDOI
N 6 -Methyladenosine co-transcriptionally directs the demethylation of histone H3K9me2.
Yuan Li,Linjian Xia,Kaifen Tan,Xidong Ye,Zhixiang Zuo,Minchun Li,Rui Xiao,Zihan Wang,Xiaona Liu,Mingqiang Deng,Jinru Cui,Mengtian Yang,Qizhi Luo,Sun Liu,Xin Cao,Haoran Zhu,Tianqi Liu,Jiaxin Hu,Junfang Shi,Shan Xiao,Laixin Xia +20 more
TL;DR: It is shown that the repressive histone mark H3K9me2 is specifically removed by the induction of m6A-modified transcripts, and mechanistic insight into the co-transcriptional interplay between RNA modifications and histone modifications is provided.
Journal ArticleDOI
Methylation of proteins involved in translation
Bogdan Polevoda,Fred Sherman +1 more
TL;DR: Differential methylation of specific RPs and TFs in a number of organisms at different physiological states indicates that this modification may play a regulatory role.
Journal ArticleDOI
Epigenetic control of epithelial-to-mesenchymal transition and cancer metastasis.
Yan Wang,Yongfeng Shang +1 more
TL;DR: The therapeutic potentials of epigenetic drugs, such as DNA demethylating drugs and histone deacetylase/demethylase inhibitors, which can act upon metastasis-related genes, restoring their expression and biological functions are broadened.
References
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Journal ArticleDOI
Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
Journal ArticleDOI
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Ru Cao,Liangjun Wang,Hengbin Wang,Li Xia,Hediye Erdjument-Bromage,Paul Tempst,Richard S. Jones,Yi Zhang +7 more
TL;DR: The purification and characterization of an EED-EZH2 complex, the human counterpart of the Drosophila ESC-E(Z) complex, is reported, and it is demonstrated that the complex specifically methylates nucleosomal histone H3 at lysine 27 (H3-K27).
Journal ArticleDOI
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
TL;DR: It is shown that mammalian methyltransferases that selectively methylate histone H3 on lysine 9 (Suv39h HMTases) generate a binding site for HP1 proteins—a family of heterochromatic adaptor molecules implicated in both gene silencing and supra-nucleosomal chromatin structure.
Journal ArticleDOI
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.
Andrew J. Bannister,Philip Zegerman,Janet F. Partridge,Eric A. Miska,Jean O. Thomas,Robin C. Allshire,Tony Kouzarides +6 more
TL;DR: A stepwise model for the formation of a transcriptionally silent heterochromatin is provided: SUV39H1 places a ‘methyl marker’ on histone H3, which is then recognized by HP1 through its chromo domain, which may also explain the stable inheritance of theheterochromatic state.
Journal ArticleDOI
Regulation of chromatin structure by site-specific histone H3 methyltransferases
Stephen Rea,Frank Eisenhaber,Dónal O'Carroll,Brian D. Strahl,Zu-Wen Sun,Manfred Schmid,Susanne Opravil,Karl Mechtler,Chris P. Ponting,C D Allis,Thomas Jenuwein +10 more
TL;DR: A functional interdependence of site-specific H3 tail modifications is revealed and a dynamic mechanism for the regulation of higher-order chromatin is suggested.