PatentDOI
Histone demethylation mediated by the nuclear amine oxidase homolog lsd1
Yang Shi,Yujiang Shi +1 more
TLDR
In this paper, the authors identify a histone demethylase conserved from S. pombe to human and reveal dynamic regulation of histone methylation by both histonemethylases and demethylases.About:
This article is published in Cell.The article was published on 2005-12-16. It has received 3281 citations till now. The article focuses on the topics: Histone lysine demethylation & Histone demethylation.read more
Citations
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Journal ArticleDOI
Deregulated expression of selected histone methylases and demethylases in prostate carcinoma
Filipa Vieira,Pedro Costa-Pinheiro,João Ramalho-Carvalho,Andreia T. Pereira,Francisco Duarte Menezes,Luís Antunes,Isa Carneiro,Jorge Oliveira,Rui Henrique,Carmen Jerónimo +9 more
TL;DR: It is concluded that expression profiling of HMTs and HDMs, especially SMYD3, might be of clinical usefulness for the assessment of PCa patients and assist in pre-therapeutic decision-making.
Journal ArticleDOI
Dynamic RNA modifications in disease.
Arne Klungland,John Arne Dahl +1 more
TL;DR: The presence of 6-methyladenosine (m6A) modifications in mRNA was noted several decades ago, but the first enzyme reversing this modification was identified very recently, and two demethylases that remove it have been identified-FTO (ALKBH9 and ALKBH5.
Journal ArticleDOI
Grasping trimethylation of histone H3 at lysine 4
TL;DR: The recent progress related to the biochemistry and biology of this histone mark, including its relevant 'writers' and 'readers', are highlighted and the complex regulatory mechanisms that are involved in establishing H3K4me3 in health and disease are outlined.
Journal ArticleDOI
Laser Microdissection of Narrow Sheath Mutant Maize Uncovers Novel Gene Expression in the Shoot Apical Meristem
Xiaolan Zhang,Shahinez Madi,Lisa A. Borsuk,Dan Nettleton,Robert J. Elshire,Brent Buckner,Diane Janick-Buckner,Jon Beck,Marja C.P. Timmermans,Patrick S. Schnable,Michael J. Scanlon,Michael J. Scanlon +11 more
TL;DR: Using laser microdissection microarray to perform transcriptional profiling of the maize shoot apical meristem (SAM), a ~100-μm pillar of organogenic cells that is required for leaf initiation, reveals potentially conserved WOX gene functions and implicate specific hormonal and signaling pathways during early events in maize leaf development.
Journal ArticleDOI
Overexpression of lysine specific demethylase 1 predicts worse prognosis in primary hepatocellular carcinoma patients.
Ze-Kun Zhao,Hai-Feng Yu,Dao-Rong Wang,Ping Dong,Lei Chen,Wenguang Wu,Wen-Jun Ding,Ying-bin Liu +7 more
TL;DR: The data suggest for the first time that the overexpression of LSD1 protein in HCC tissues indicates tumor progression and predicts poor prognosis.
References
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Journal ArticleDOI
Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
Journal ArticleDOI
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Ru Cao,Liangjun Wang,Hengbin Wang,Li Xia,Hediye Erdjument-Bromage,Paul Tempst,Richard S. Jones,Yi Zhang +7 more
TL;DR: The purification and characterization of an EED-EZH2 complex, the human counterpart of the Drosophila ESC-E(Z) complex, is reported, and it is demonstrated that the complex specifically methylates nucleosomal histone H3 at lysine 27 (H3-K27).
Journal ArticleDOI
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
TL;DR: It is shown that mammalian methyltransferases that selectively methylate histone H3 on lysine 9 (Suv39h HMTases) generate a binding site for HP1 proteins—a family of heterochromatic adaptor molecules implicated in both gene silencing and supra-nucleosomal chromatin structure.
Journal ArticleDOI
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.
Andrew J. Bannister,Philip Zegerman,Janet F. Partridge,Eric A. Miska,Jean O. Thomas,Robin C. Allshire,Tony Kouzarides +6 more
TL;DR: A stepwise model for the formation of a transcriptionally silent heterochromatin is provided: SUV39H1 places a ‘methyl marker’ on histone H3, which is then recognized by HP1 through its chromo domain, which may also explain the stable inheritance of theheterochromatic state.
Journal ArticleDOI
Regulation of chromatin structure by site-specific histone H3 methyltransferases
Stephen Rea,Frank Eisenhaber,Dónal O'Carroll,Brian D. Strahl,Zu-Wen Sun,Manfred Schmid,Susanne Opravil,Karl Mechtler,Chris P. Ponting,C D Allis,Thomas Jenuwein +10 more
TL;DR: A functional interdependence of site-specific H3 tail modifications is revealed and a dynamic mechanism for the regulation of higher-order chromatin is suggested.