PatentDOI
Histone demethylation mediated by the nuclear amine oxidase homolog lsd1
Yang Shi,Yujiang Shi +1 more
TLDR
In this paper, the authors identify a histone demethylase conserved from S. pombe to human and reveal dynamic regulation of histone methylation by both histonemethylases and demethylases.About:
This article is published in Cell.The article was published on 2005-12-16. It has received 3281 citations till now. The article focuses on the topics: Histone lysine demethylation & Histone demethylation.read more
Citations
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Journal ArticleDOI
Long non-coding RNA: A new paradigm for lung cancer.
TL;DR: A comprehensive survey of lncRNAs associated with lung cancer is provided, with particular focus on the functions that either facilitate or inhibit the progression of lung cancer and the pathways involved.
Journal ArticleDOI
Methylation of aquaporins in plant plasma membrane.
Véronique Santoni,Lionel Verdoucq,Nicolas Sommerer,Joëlle Vinh,Delphine Pflieger,Christophe Maurel +5 more
TL;DR: The present study identifies methylation as a novel post-translational modification of aquaporins, and even plant membrane proteins, and may represent a critical advance towards the identification of new regulatory mechanisms of membrane transport.
Journal ArticleDOI
Histone methylation modifiers in cellular signaling pathways.
TL;DR: The role of histone methylation modifiers in regulating the following signaling pathways is summarized: NF-κB, RAS/RAF/MEK/MAPK, PI3K/Akt, Wnt/β-catenin, p53, and ERα.
Journal ArticleDOI
A selective phenelzine analogue inhibitor of histone demethylase LSD1.
Polina Prusevich,Jay H. Kalin,Shonoi Ming,Manuela Basso,Jeffrey Givens,Xin Li,Jianfei Hu,Martin S. Taylor,Anne M. Cieniewicz,Po Yuan Hsiao,Rong Huang,Rong Huang,Heather Roberson,Nkosi Adejola,Lindsay B. Avery,Robert A. Casero,Sean D. Taverna,Jiang Qian,Alan J. Tackett,Rajiv R. Ratan,Oliver G. McDonald,Andrew P. Feinberg,Philip A. Cole +22 more
TL;DR: Bizine was found to be effective at modulating bulk histone methylation in cancer cells, and ChIP-seq experiments revealed a statistically significant overlap in the H3K4 methylation pattern of genes affected by bizine and those altered in LSD1–/– cells, suggesting potential applications in neurodegenerative disease.
Journal ArticleDOI
Phosphorylation of LSD1 by PKCα Is Crucial for Circadian Rhythmicity and Phase Resetting
Hye Jin Nam,Kyungjin Boo,Dong Ha Kim,Dong Hee Han,Han Kyoung Choe,Chang Rok Kim,Woong Sun,Hyun Kim,Kyungjin Kim,Ho Lee,Eric Metzger,Roland Schuele,Seung Hee Yoo,Joseph S. Takahashi,Se-Hyung Cho,Gi Hoon Son,Sung Hee Baek +16 more
TL;DR: Evidence is provided that the lysine-specific demethylase 1 (LSD1) is phosphorylated by protein kinase Cα (PKCα) in a circadian manner and theosphorylated LSD1 forms a complex with CLOCK:BMAL1 to facilitate E-box-mediated transcriptional activation.
References
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Journal ArticleDOI
Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
Journal ArticleDOI
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Ru Cao,Liangjun Wang,Hengbin Wang,Li Xia,Hediye Erdjument-Bromage,Paul Tempst,Richard S. Jones,Yi Zhang +7 more
TL;DR: The purification and characterization of an EED-EZH2 complex, the human counterpart of the Drosophila ESC-E(Z) complex, is reported, and it is demonstrated that the complex specifically methylates nucleosomal histone H3 at lysine 27 (H3-K27).
Journal ArticleDOI
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
TL;DR: It is shown that mammalian methyltransferases that selectively methylate histone H3 on lysine 9 (Suv39h HMTases) generate a binding site for HP1 proteins—a family of heterochromatic adaptor molecules implicated in both gene silencing and supra-nucleosomal chromatin structure.
Journal ArticleDOI
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.
Andrew J. Bannister,Philip Zegerman,Janet F. Partridge,Eric A. Miska,Jean O. Thomas,Robin C. Allshire,Tony Kouzarides +6 more
TL;DR: A stepwise model for the formation of a transcriptionally silent heterochromatin is provided: SUV39H1 places a ‘methyl marker’ on histone H3, which is then recognized by HP1 through its chromo domain, which may also explain the stable inheritance of theheterochromatic state.
Journal ArticleDOI
Regulation of chromatin structure by site-specific histone H3 methyltransferases
Stephen Rea,Frank Eisenhaber,Dónal O'Carroll,Brian D. Strahl,Zu-Wen Sun,Manfred Schmid,Susanne Opravil,Karl Mechtler,Chris P. Ponting,C D Allis,Thomas Jenuwein +10 more
TL;DR: A functional interdependence of site-specific H3 tail modifications is revealed and a dynamic mechanism for the regulation of higher-order chromatin is suggested.