PatentDOI
Histone demethylation mediated by the nuclear amine oxidase homolog lsd1
Yang Shi,Yujiang Shi +1 more
TLDR
In this paper, the authors identify a histone demethylase conserved from S. pombe to human and reveal dynamic regulation of histone methylation by both histonemethylases and demethylases.About:
This article is published in Cell.The article was published on 2005-12-16. It has received 3281 citations till now. The article focuses on the topics: Histone lysine demethylation & Histone demethylation.read more
Citations
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Journal ArticleDOI
Chromatin Modifications and Their Function
TL;DR: The surface of nucleosomes is studded with a multiplicity of modifications that can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA.
Journal ArticleDOI
Regulation of chromatin by histone modifications
TL;DR: The known histone modifications are described, where they are found genomically and discussed and some of their functional consequences are discussed, concentrating mostly on transcription where the majority of characterisation has taken place.
Journal ArticleDOI
Epigenetics in Cancer
TL;DR: The current understanding of alterations in the epigenetic landscape that occur in cancer compared with normal cells, the roles of these changes in cancer initiation and progression, including the cancer stem cell model, and the potential use of this knowledge in designing more effective treatment strategies are discussed.
Journal ArticleDOI
The Emerging Hallmarks of Cancer Metabolism
TL;DR: This Perspective has organized known cancer-associated metabolic changes into six hallmarks: deregulated uptake of glucose and amino acids, use of opportunistic modes of nutrient acquisition, useof glycolysis/TCA cycle intermediates for biosynthesis and NADPH production, increased demand for nitrogen, alterations in metabolite-driven gene regulation, and metabolic interactions with the microenvironment.
Journal ArticleDOI
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
Miao-Chih Tsai,Ohad Manor,Yue Wan,Nima Mosammaparast,Jordon K. Wang,Fei Lan,Yang Shi,Eran Segal,Howard Y. Chang +8 more
TL;DR: The results suggest that lincRNAs may serve as scaffolds by providing binding surfaces to assemble select histone modification enzymes, thereby specifying the pattern of histone modifications on target genes.
References
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Journal ArticleDOI
Proteolytic processing of histone H3 in chromatin: a physiologically regulated event in tetrahymena micronuclei
TL;DR: Automated sequence analyses demonstrated that H3F is derived from H3S by a proteolytic cleavage which removes six residues from the amino terminus, the first demonstration of a physiologically regulated proteolytics processing event in histone metabolism.
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B cell-specific loss of histone 3 lysine 9 methylation in the V(H) locus depends on Pax5.
Kristen Johnson,David L. Pflugh,Duonan Yu,David G.T. Hesslein,Kuo-I Lin,Alfred L. M. Bothwell,Andrei Thomas-Tikhonenko,David G. Schatz,David G. Schatz,Kathryn Calame +9 more
TL;DR: It is shown that Pax5, a transcription factor required for B cell commitment, is necessary and sufficient for the removal of H3-K9 methylation in the VH locus and evidence that one function of Pax5 is to remove this inhibitory modification by a mechanism of histone exchange, thus allowing B cell–specific VH-to-DJH recombination.
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The SWIRM domain: a conserved module found in chromosomal proteins points to novel chromatin-modifying activities.
TL;DR: It is predicted that the proteins in which the SWIRM domain is combined with an amino-oxidase domain define a novel class of chromatin-modifying enzymes, which are likely to oxidize either the amino group of basic residues in histones and other chromosomal proteins or the polyamines in chromatin, and thereby alter the charge distribution.
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Enzymatic demethylation of calf thymus histones.
Woon Ki Paik,Sangduk Kim +1 more
TL;DR: Investigation of enzymatic demethylation of e-N-methyllysine residues of calf thymus histone finds kidney contains the highest enzyme activity among the rat organs tested, and the enzyme activity is associated with the nuclear and mitocondrial fractions.
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Metabolic enzymes and coenzymes in transcription--a direct link between metabolism and transcription?
Yujiang Shi,Yang Shi +1 more
TL;DR: This article focuses on the recent advances in deciphering the roles and mechanisms of action of metabolic cofactors and enzymes in regulated transcription.