PatentDOI
Histone demethylation mediated by the nuclear amine oxidase homolog lsd1
Yang Shi,Yujiang Shi +1 more
TLDR
In this paper, the authors identify a histone demethylase conserved from S. pombe to human and reveal dynamic regulation of histone methylation by both histonemethylases and demethylases.About:
This article is published in Cell.The article was published on 2005-12-16. It has received 3281 citations till now. The article focuses on the topics: Histone lysine demethylation & Histone demethylation.read more
Citations
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Journal ArticleDOI
Androgen Receptor Tumor Suppressor Function Is Mediated by Recruitment of Retinoblastoma Protein
Shuai Gao,Shuai Gao,Yanfei Gao,Yanfei Gao,Housheng Hansen He,Dong Han,Wanting Han,Amy Avery,Jill A. Macoska,Xiaming Liu,Sen Chen,Fen Ma,Shaoyong Chen,Steven P. Balk,Changmeng Cai,Changmeng Cai +15 more
TL;DR: In castration-resistant PCa cells, which are dependent on high-level AR expression, this anti-proliferative repression function might be exploited through treatment with androgen in combination with agents that suppress AR-driven metabolic functions or cell cycle progression.
Journal ArticleDOI
The Promise for Histone Methyltransferase Inhibitors for Epigenetic Therapy in Clinical Oncology: A Narrative Review.
Hope S. Rugo,Ira Jacobs,Shikhar Sharma,Frank Scappaticci,Thomas A Paul,Kristen Jensen-Pergakes,Gabriel G. Malouf +6 more
TL;DR: This review focuses on histone methyltransferase inhibitors, highlighting their potential in the treatment of cancer and the role for such epigenetic drugs in overcoming epigenetically driven drug resistance mechanisms, and their value in combination with other therapeutic approaches such as immunotherapy.
Journal ArticleDOI
A novel LSD1 inhibitor NCD38 ameliorates MDS-related leukemia with complex karyotype by attenuating leukemia programs via activating super-enhancers.
Noriko Sugino,Masahiro Kawahara,Masahiro Kawahara,Goichi Tatsumi,Akinori Kanai,Hirotaka Matsui,Hirotaka Matsui,Ryusuke Yamamoto,Yuya Nagai,Sumie Fujii,Yayoi Shimazu,Masakatsu Hishizawa,Toshiya Inaba,Akira Andoh,Takayoshi Suzuki,Akifumi Takaori-Kondo +15 more
TL;DR: Together, NCD38 derepresses super-enhancers of hematopoietic regulators that are silenced abnormally by LSD1, attenuates leukemogenic programs and consequently exerts anti-leukemic effect against MDS-related leukemia with adverse outcome.
Journal ArticleDOI
Regulation of gene expression in the nervous system.
Lezanne Ooi,Ian C. Wood +1 more
TL;DR: Some recent insights are highlighted into the gene-regulatory circuits in the development and differentiation of cells within the nervous system and some of the mechanisms by which synaptic transmission influences transcription-factor activity in the mature nervous system are discussed.
Journal ArticleDOI
Histone demethylase LSD1 controls the phenotypic plasticity of cancer cells.
TL;DR: An overview of how LSD1 epigenetically regulates cellular plasticity through distinct molecular mechanisms in different biological contexts is presented and targeted inhibition of the context‐dependent activities of LSD1 may provide a highly selective means to eliminate cancer cells.
References
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Journal ArticleDOI
Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
Journal ArticleDOI
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Ru Cao,Liangjun Wang,Hengbin Wang,Li Xia,Hediye Erdjument-Bromage,Paul Tempst,Richard S. Jones,Yi Zhang +7 more
TL;DR: The purification and characterization of an EED-EZH2 complex, the human counterpart of the Drosophila ESC-E(Z) complex, is reported, and it is demonstrated that the complex specifically methylates nucleosomal histone H3 at lysine 27 (H3-K27).
Journal ArticleDOI
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
TL;DR: It is shown that mammalian methyltransferases that selectively methylate histone H3 on lysine 9 (Suv39h HMTases) generate a binding site for HP1 proteins—a family of heterochromatic adaptor molecules implicated in both gene silencing and supra-nucleosomal chromatin structure.
Journal ArticleDOI
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.
Andrew J. Bannister,Philip Zegerman,Janet F. Partridge,Eric A. Miska,Jean O. Thomas,Robin C. Allshire,Tony Kouzarides +6 more
TL;DR: A stepwise model for the formation of a transcriptionally silent heterochromatin is provided: SUV39H1 places a ‘methyl marker’ on histone H3, which is then recognized by HP1 through its chromo domain, which may also explain the stable inheritance of theheterochromatic state.
Journal ArticleDOI
Regulation of chromatin structure by site-specific histone H3 methyltransferases
Stephen Rea,Frank Eisenhaber,Dónal O'Carroll,Brian D. Strahl,Zu-Wen Sun,Manfred Schmid,Susanne Opravil,Karl Mechtler,Chris P. Ponting,C D Allis,Thomas Jenuwein +10 more
TL;DR: A functional interdependence of site-specific H3 tail modifications is revealed and a dynamic mechanism for the regulation of higher-order chromatin is suggested.