PatentDOI
Histone demethylation mediated by the nuclear amine oxidase homolog lsd1
Yang Shi,Yujiang Shi +1 more
TLDR
In this paper, the authors identify a histone demethylase conserved from S. pombe to human and reveal dynamic regulation of histone methylation by both histonemethylases and demethylases.About:
This article is published in Cell.The article was published on 2005-12-16. It has received 3281 citations till now. The article focuses on the topics: Histone lysine demethylation & Histone demethylation.read more
Citations
More filters
Journal ArticleDOI
Chromatin Modifications and Their Function
TL;DR: The surface of nucleosomes is studded with a multiplicity of modifications that can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA.
Journal ArticleDOI
Regulation of chromatin by histone modifications
TL;DR: The known histone modifications are described, where they are found genomically and discussed and some of their functional consequences are discussed, concentrating mostly on transcription where the majority of characterisation has taken place.
Journal ArticleDOI
Epigenetics in Cancer
TL;DR: The current understanding of alterations in the epigenetic landscape that occur in cancer compared with normal cells, the roles of these changes in cancer initiation and progression, including the cancer stem cell model, and the potential use of this knowledge in designing more effective treatment strategies are discussed.
Journal ArticleDOI
The Emerging Hallmarks of Cancer Metabolism
TL;DR: This Perspective has organized known cancer-associated metabolic changes into six hallmarks: deregulated uptake of glucose and amino acids, use of opportunistic modes of nutrient acquisition, useof glycolysis/TCA cycle intermediates for biosynthesis and NADPH production, increased demand for nitrogen, alterations in metabolite-driven gene regulation, and metabolic interactions with the microenvironment.
Journal ArticleDOI
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
Miao-Chih Tsai,Ohad Manor,Yue Wan,Nima Mosammaparast,Jordon K. Wang,Fei Lan,Yang Shi,Eran Segal,Howard Y. Chang +8 more
TL;DR: The results suggest that lincRNAs may serve as scaffolds by providing binding surfaces to assemble select histone modification enzymes, thereby specifying the pattern of histone modifications on target genes.
References
More filters
Journal ArticleDOI
Correlation Between Histone Lysine Methylation and Developmental Changes at the Chicken β-Globin Locus
TL;DR: A mechanism by which the insulator in the β-globin locus can protect the globin genes from being silenced by adjacent condensed chromatin is proposed.
Journal ArticleDOI
Histone methylation: dynamic or static?
TL;DR: The methyl group of histones mediates transcriptional silencing at heterochromatin sites and affects regulated transcription at euchromatic loci and can be removed by an active process necessary for regulated gene expression.
Journal ArticleDOI
PR-Set7 Is a Nucleosome-Specific Methyltransferase that Modifies Lysine 20 of Histone H4 and Is Associated with Silent Chromatin
Kenichi Nishioka,Judd C. Rice,Kavitha Sarma,Hediye Erdjument-Bromage,Janis Werner,Yanming Wang,Sergei Chuikov,Pablo Valenzuela,Paul Tempst,Ruth Steward,John T. Lis,C. David Allis,Danny Reinberg +12 more
TL;DR: The hypothesis that methylation of H4 lysine 20 maintains silent chromatin, in part, by precluding neighboring acetylation on the H4 tail is supported.
Journal ArticleDOI
CoREST is an integral component of the CoREST- human histone deacetylase complex
TL;DR: CoREST-HDAC is composed of polypeptides distinct from previously characterized HDAC1/2-containing complexes such as the mSin3 and nucleosome remodeling and deacetylating (NRD), and it is demonstrated that the corepressor function of CoREST depends on this region.
Journal ArticleDOI
Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins.
Paul M. Ayton,Michael L. Cleary +1 more
TL;DR: Interestingly, whilst all MLL fusion proteins tested so far phenocopy each other with respect to in vitro immortalization, the latency period required for the onset of acute leukemia in vivo is variable and partner protein dependent.