PatentDOI
Histone demethylation mediated by the nuclear amine oxidase homolog lsd1
Yang Shi,Yujiang Shi +1 more
TLDR
In this paper, the authors identify a histone demethylase conserved from S. pombe to human and reveal dynamic regulation of histone methylation by both histonemethylases and demethylases.About:
This article is published in Cell.The article was published on 2005-12-16. It has received 3281 citations till now. The article focuses on the topics: Histone lysine demethylation & Histone demethylation.read more
Citations
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Journal ArticleDOI
DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymes
Eriko G. Clements,Helai P. Mohammad,Benjamin Leadem,Hariharan Easwaran,Yi Cai,Leander Van Neste,Stephen B. Baylin +6 more
TL;DR: The findings show that there are genes for which DNMT1 acts as a transcriptional repressor independent from its methyltransferase function and that this repressive function may invoke a role for a scaffolding function of the protein at target genes.
Journal ArticleDOI
Emerging roles of lysine methylation on non-histone proteins
TL;DR: This review will use p53 and nuclear receptors, especially estrogen receptor alpha, as examples to discuss the dynamic nature of non-histone protein lysine methylation, the writers, erasers, and readers of these modifications, and the crosstalk between lysines methylation and other PTMs in regulating the functions of the modified proteins.
Journal ArticleDOI
Asymmetric Arginine Dimethylation of Heterogeneous Nuclear Ribonucleoprotein K by Protein-arginine Methyltransferase 1 Inhibits Its Interaction with c-Src
Antje Ostareck-Lederer,Dirk H. Ostareck,Karl Peter Rücknagel,Angelika Schierhorn,Bodo Moritz,Stefan Hüttelmaier,Nadine Flach,Lusy Handoko,Elmar Wahle +8 more
TL;DR: Findings support the role of arginine methylation in the regulation of protein-protein interactions in RNA-binding proteins.
Journal ArticleDOI
LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer
Tara Boulding,Robert McCuaig,Abel Tan,Kristine Hardy,Fan Wu,J. Dunn,Murugan Kalimutho,Christopher Sutton,Jade K. Forwood,Andrew G. Bert,Gregory J. Goodall,Laeeq Malik,Desmond Yip,Desmond Yip,Jane E. Dahlstrom,Anjum Zafar,K. K. Khanna,Sudha Rao +17 more
TL;DR: In vivo, chemotherapy reduced tumour volume, and when combined with an LSD1 inhibitor, abrogated the mesenchymal signature and promoted an innate, M1 macrophage-like tumouricidal immune response.
Journal ArticleDOI
Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1).
Naoki Sakane,Hye-Sook Kwon,Sara Pagans,Katrin Kaehlcke,Yasuhiro Mizusawa,Masafumi Kamada,Kara G. Lassen,Jonathan K.L. Chan,Warner C. Greene,Martina Schnoelzer,Melanie Ott +10 more
TL;DR: The model that a LSD1/KDM1/CoREST complex, normally known as a transcriptional suppressor, acts as a novel activator of HIV transcription through demethylation of K51 in Tat is supported.
References
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Journal ArticleDOI
Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
Journal ArticleDOI
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Ru Cao,Liangjun Wang,Hengbin Wang,Li Xia,Hediye Erdjument-Bromage,Paul Tempst,Richard S. Jones,Yi Zhang +7 more
TL;DR: The purification and characterization of an EED-EZH2 complex, the human counterpart of the Drosophila ESC-E(Z) complex, is reported, and it is demonstrated that the complex specifically methylates nucleosomal histone H3 at lysine 27 (H3-K27).
Journal ArticleDOI
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
TL;DR: It is shown that mammalian methyltransferases that selectively methylate histone H3 on lysine 9 (Suv39h HMTases) generate a binding site for HP1 proteins—a family of heterochromatic adaptor molecules implicated in both gene silencing and supra-nucleosomal chromatin structure.
Journal ArticleDOI
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.
Andrew J. Bannister,Philip Zegerman,Janet F. Partridge,Eric A. Miska,Jean O. Thomas,Robin C. Allshire,Tony Kouzarides +6 more
TL;DR: A stepwise model for the formation of a transcriptionally silent heterochromatin is provided: SUV39H1 places a ‘methyl marker’ on histone H3, which is then recognized by HP1 through its chromo domain, which may also explain the stable inheritance of theheterochromatic state.
Journal ArticleDOI
Regulation of chromatin structure by site-specific histone H3 methyltransferases
Stephen Rea,Frank Eisenhaber,Dónal O'Carroll,Brian D. Strahl,Zu-Wen Sun,Manfred Schmid,Susanne Opravil,Karl Mechtler,Chris P. Ponting,C D Allis,Thomas Jenuwein +10 more
TL;DR: A functional interdependence of site-specific H3 tail modifications is revealed and a dynamic mechanism for the regulation of higher-order chromatin is suggested.