PatentDOI
Histone demethylation mediated by the nuclear amine oxidase homolog lsd1
Yang Shi,Yujiang Shi +1 more
TLDR
In this paper, the authors identify a histone demethylase conserved from S. pombe to human and reveal dynamic regulation of histone methylation by both histonemethylases and demethylases.About:
This article is published in Cell.The article was published on 2005-12-16. It has received 3281 citations till now. The article focuses on the topics: Histone lysine demethylation & Histone demethylation.read more
Citations
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Journal ArticleDOI
Heterochromatin protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase.
Chia-Hui Lin,Bing Li,Selene K. Swanson,Ying Zhang,Laurence Florens,Michael P. Washburn,Susan M. Abmayr,Jerry L. Workman +7 more
TL;DR: It is reported that a Drosophila melanogaster JmjC domain-containing protein, dKDM4A, is a histone H3K36 demethylase, and in vivo evidence suggesting that heterochromatin protein 1a (HP1a) associates with dKDMA4A and that loss of HP1a leads to an increased level of hist one H 3K36me3.
Journal ArticleDOI
Histone lysine trimethylation exhibits a distinct perinuclear distribution in Plzf-expressing spermatogonia
TL;DR: It is shown that Plzf-expressing spermatogonia completely lack monomethyl-H3-K27 and monometo-H4-K20, and contain very little monomet h2O, a sign of the possible importance of different histone lysine methylation states in the epigenetic control of sperMatogenesis.
Journal ArticleDOI
Epigenetics in teleost fish: From molecular mechanisms to physiological phenotypes.
Carol Best,Heather Ikert,Daniel J. Kostyniuk,Paul M. Craig,Laia Navarro-Martín,Lucie Marandel,Jan A. Mennigen +6 more
TL;DR: The evolution of the repertoire of genes involved in key molecular epigenetic pathways including histone modifications, DNA methylation and microRNAs in zebrafish, rainbow trout, and Atlantic salmon are described.
Journal ArticleDOI
LSD1 promotes oxidative metabolism of white adipose tissue
Delphine Duteil,Eric Metzger,Dominica Willmann,Panagiota Karagianni,Nicolaus Friedrichs,Holger Greschik,Thomas Günther,Reinhard Buettner,Iannis Talianidis,Daniel Metzger,Roland Schüle +10 more
TL;DR: Genome-wide binding and transcriptome analyses demonstrate that LSD1 directly stimulates the expression of genes involved in oxidative phosphorylation (OXPHOS) in cooperation with nuclear respiratory factor 1 (Nrf1) and establish LSD1 as a key regulator of OXPHOS and metabolic adaptation in WAT.
Journal ArticleDOI
Cancer treatment of the future: inhibitors of histone methyltransferases.
TL;DR: Since connections between histone methylation patterns and cancer progression have been recognized, hist one methyltransferases represent promising targets for future cancer treatment.
References
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Journal ArticleDOI
Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
Journal ArticleDOI
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Ru Cao,Liangjun Wang,Hengbin Wang,Li Xia,Hediye Erdjument-Bromage,Paul Tempst,Richard S. Jones,Yi Zhang +7 more
TL;DR: The purification and characterization of an EED-EZH2 complex, the human counterpart of the Drosophila ESC-E(Z) complex, is reported, and it is demonstrated that the complex specifically methylates nucleosomal histone H3 at lysine 27 (H3-K27).
Journal ArticleDOI
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
TL;DR: It is shown that mammalian methyltransferases that selectively methylate histone H3 on lysine 9 (Suv39h HMTases) generate a binding site for HP1 proteins—a family of heterochromatic adaptor molecules implicated in both gene silencing and supra-nucleosomal chromatin structure.
Journal ArticleDOI
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.
Andrew J. Bannister,Philip Zegerman,Janet F. Partridge,Eric A. Miska,Jean O. Thomas,Robin C. Allshire,Tony Kouzarides +6 more
TL;DR: A stepwise model for the formation of a transcriptionally silent heterochromatin is provided: SUV39H1 places a ‘methyl marker’ on histone H3, which is then recognized by HP1 through its chromo domain, which may also explain the stable inheritance of theheterochromatic state.
Journal ArticleDOI
Regulation of chromatin structure by site-specific histone H3 methyltransferases
Stephen Rea,Frank Eisenhaber,Dónal O'Carroll,Brian D. Strahl,Zu-Wen Sun,Manfred Schmid,Susanne Opravil,Karl Mechtler,Chris P. Ponting,C D Allis,Thomas Jenuwein +10 more
TL;DR: A functional interdependence of site-specific H3 tail modifications is revealed and a dynamic mechanism for the regulation of higher-order chromatin is suggested.