PatentDOI
Histone demethylation mediated by the nuclear amine oxidase homolog lsd1
Yang Shi,Yujiang Shi +1 more
TLDR
In this paper, the authors identify a histone demethylase conserved from S. pombe to human and reveal dynamic regulation of histone methylation by both histonemethylases and demethylases.About:
This article is published in Cell.The article was published on 2005-12-16. It has received 3281 citations till now. The article focuses on the topics: Histone lysine demethylation & Histone demethylation.read more
Citations
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Journal ArticleDOI
A Highly Specific Mechanism of Histone H3-K4 Recognition by Histone Demethylase LSD1
Federico Forneris,Claudia Binda,Annachiara Dall'Aglio,Marco W. Fraaije,Elena Battaglioli,Andrea Mattevi +5 more
TL;DR: The results show that epigenetic modifications on histone H3 need to be removed before Lys4 demethylation can efficiently occur, and suggest that after H3-K4 dem methylation, LSD1 recruits the forthcoming chromatin remodelers leading to the introduction of gene repression marks.
Journal ArticleDOI
Structural basis of the recognition of a methylated histone tail by JMJD2A.
Zhongzhou Chen,Jianye Zang,John W. Kappler,Xia Hong,Frances Crawford,Qin Wang,Fei Lan,Chengyu Jiang,Johnathan R. Whetstine,Shaodong Dai,Kirk C. Hansen,Yang Shi,Gongyi Zhang +12 more
TL;DR: Structures of the JMJD2A catalytic core complexed with methylated H3K36 peptide substrates in the presence of Fe(II) and N-oxalylglycine are presented to provide insights into the mechanisms and specificity of histone demethylation.
Journal ArticleDOI
Long noncoding RNAs: new insights into non-small cell lung cancer biology, diagnosis and therapy.
Biagio Ricciuti,Clelia Mencaroni,Luca Paglialunga,Francesco Paciullo,Lucio Crinò,Rita Chiari,Giulio Metro +6 more
TL;DR: A comprehensive review of the published literature focusing on lncRNAs function and disruption in nonsmall cell lung cancer biology, also highlighting their value as biomarkers and potential therapeutic targets is conducted.
Journal ArticleDOI
Histone modifications and chromatin dynamics: a focus on filamentous fungi
TL;DR: This review aims at summarizing the roles of histone H1 and the acetylation and methylation of histones in filamentous fungi and links this knowledge to the huge body of data from other systems.
Journal ArticleDOI
The epigenome as a therapeutic target in prostate cancer
TL;DR: Promoter hypermethylation is widespread during neoplastic transformation of prostate cells, which suggests that restoration of a 'normal' epigenome through treatment with inhibitors of the enzymes involved could be clinically beneficial and a potential treatment option for patients with advanced disease.
References
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Journal ArticleDOI
Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
Journal ArticleDOI
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Ru Cao,Liangjun Wang,Hengbin Wang,Li Xia,Hediye Erdjument-Bromage,Paul Tempst,Richard S. Jones,Yi Zhang +7 more
TL;DR: The purification and characterization of an EED-EZH2 complex, the human counterpart of the Drosophila ESC-E(Z) complex, is reported, and it is demonstrated that the complex specifically methylates nucleosomal histone H3 at lysine 27 (H3-K27).
Journal ArticleDOI
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
TL;DR: It is shown that mammalian methyltransferases that selectively methylate histone H3 on lysine 9 (Suv39h HMTases) generate a binding site for HP1 proteins—a family of heterochromatic adaptor molecules implicated in both gene silencing and supra-nucleosomal chromatin structure.
Journal ArticleDOI
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.
Andrew J. Bannister,Philip Zegerman,Janet F. Partridge,Eric A. Miska,Jean O. Thomas,Robin C. Allshire,Tony Kouzarides +6 more
TL;DR: A stepwise model for the formation of a transcriptionally silent heterochromatin is provided: SUV39H1 places a ‘methyl marker’ on histone H3, which is then recognized by HP1 through its chromo domain, which may also explain the stable inheritance of theheterochromatic state.
Journal ArticleDOI
Regulation of chromatin structure by site-specific histone H3 methyltransferases
Stephen Rea,Frank Eisenhaber,Dónal O'Carroll,Brian D. Strahl,Zu-Wen Sun,Manfred Schmid,Susanne Opravil,Karl Mechtler,Chris P. Ponting,C D Allis,Thomas Jenuwein +10 more
TL;DR: A functional interdependence of site-specific H3 tail modifications is revealed and a dynamic mechanism for the regulation of higher-order chromatin is suggested.