PatentDOI
Histone demethylation mediated by the nuclear amine oxidase homolog lsd1
Yang Shi,Yujiang Shi +1 more
TLDR
In this paper, the authors identify a histone demethylase conserved from S. pombe to human and reveal dynamic regulation of histone methylation by both histonemethylases and demethylases.About:
This article is published in Cell.The article was published on 2005-12-16. It has received 3281 citations till now. The article focuses on the topics: Histone lysine demethylation & Histone demethylation.read more
Citations
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Journal ArticleDOI
Emerging concepts of epigenetic dysregulation in hematological malignancies
TL;DR: Recent insights into epigenetic dysregulation characteristic of the malignant differentiation of blood stem cells are described based on studies of alterations that affect epigenetic complexes, enhancers, chromatin, long noncoding RNAs, RNA splicing, nuclear topology and the 3D conformation of chromatin.
Journal ArticleDOI
The histone demethylase JMJD2C is stage-specifically expressed in preimplantation mouse embryos and is required for embryonic development.
Jianle Wang,Miao Zhang,Yu Zhang,Zhaohui Kou,Zhiming Han,Da-Yuan Chen,Qing-Yuan Sun,Shaorong Gao +7 more
TL;DR: It is found that JMJD2C is stage-specifically expressed during preimplantation development, with the highest activity being observed from the two-cell to the eight-cell stage, and the deregulation of these critical genes synergistically causes the developmental defects observed in JMJD-depleted embryos.
Journal ArticleDOI
Crystal Structure of the COMPASS H3K4 Methyltransferase Catalytic Module.
Peter L. Hsu,Heng Li,Ho-Tak Lau,Calvin Jon Antolin Leonen,Abhinav Dhall,Shao En Ong,Champak Chatterjee,Ning Zheng,Ning Zheng +8 more
TL;DR: By spatially mapping the functional components of COMPASS, the results provide a structural framework for understanding the multifaceted functions and regulation of the H3K4 methyltransferase family.
Journal ArticleDOI
miRNAs in development and pathogenesis of the nervous system.
TL;DR: The role of miRNAs in the development and pathogenesis of the human nervous system is reviewed in this article. But, the current knowledge of the role of microRNAs is limited.
Journal ArticleDOI
RNAi, heterochromatin and the cell cycle.
TL;DR: These findings suggest a model of RNAi-directed epigenetic inheritance, thereby providing an explanation for how 'silent' heterochromatin can be transcribed during the S phase of the cell cycle.
References
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Journal ArticleDOI
Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
Journal ArticleDOI
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Ru Cao,Liangjun Wang,Hengbin Wang,Li Xia,Hediye Erdjument-Bromage,Paul Tempst,Richard S. Jones,Yi Zhang +7 more
TL;DR: The purification and characterization of an EED-EZH2 complex, the human counterpart of the Drosophila ESC-E(Z) complex, is reported, and it is demonstrated that the complex specifically methylates nucleosomal histone H3 at lysine 27 (H3-K27).
Journal ArticleDOI
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
TL;DR: It is shown that mammalian methyltransferases that selectively methylate histone H3 on lysine 9 (Suv39h HMTases) generate a binding site for HP1 proteins—a family of heterochromatic adaptor molecules implicated in both gene silencing and supra-nucleosomal chromatin structure.
Journal ArticleDOI
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.
Andrew J. Bannister,Philip Zegerman,Janet F. Partridge,Eric A. Miska,Jean O. Thomas,Robin C. Allshire,Tony Kouzarides +6 more
TL;DR: A stepwise model for the formation of a transcriptionally silent heterochromatin is provided: SUV39H1 places a ‘methyl marker’ on histone H3, which is then recognized by HP1 through its chromo domain, which may also explain the stable inheritance of theheterochromatic state.
Journal ArticleDOI
Regulation of chromatin structure by site-specific histone H3 methyltransferases
Stephen Rea,Frank Eisenhaber,Dónal O'Carroll,Brian D. Strahl,Zu-Wen Sun,Manfred Schmid,Susanne Opravil,Karl Mechtler,Chris P. Ponting,C D Allis,Thomas Jenuwein +10 more
TL;DR: A functional interdependence of site-specific H3 tail modifications is revealed and a dynamic mechanism for the regulation of higher-order chromatin is suggested.