PatentDOI
Histone demethylation mediated by the nuclear amine oxidase homolog lsd1
Yang Shi,Yujiang Shi +1 more
TLDR
In this paper, the authors identify a histone demethylase conserved from S. pombe to human and reveal dynamic regulation of histone methylation by both histonemethylases and demethylases.About:
This article is published in Cell.The article was published on 2005-12-16. It has received 3281 citations till now. The article focuses on the topics: Histone lysine demethylation & Histone demethylation.read more
Citations
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Journal ArticleDOI
Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN
Julian Stingele,Roberto Bellelli,Ferdinand Alte,Graeme Hewitt,Grzegorz Sarek,Sarah L. Maslen,Susan E. Tsutakawa,Annabel Borg,Svend Kjaer,John A. Tainer,John A. Tainer,J. Mark Skehel,Michael Groll,Simon J. Boulton +13 more
TL;DR: The metalloprotease SPRTN is identified as the DPC protease acting in metazoans and provided a molecular explanation on how SPRTN deficiency causes the premature aging and cancer predisposition disorder Ruijs-Aalfs syndrome.
Journal ArticleDOI
LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription
Stefano Amente,Alessandra Bertoni,Annalisa Morano,Luigi Lania,Enrico V. Avvedimento,Barbara Majello +5 more
TL;DR: The role of transient LSD1-mediated demethylation of H3K4 leading to local DNA oxidation as driving force in the assembly of the Myc-induced transcription initiation complex is highlighted.
Journal ArticleDOI
Epigenetic aberrations during oncogenesis
TL;DR: A better understanding of the intertwined relationship between genetics, epigenetics and microRNAs is necessary in order to resolve how gene expression aberrations that contribute to tumorigenesis can be therapeutically corrected.
Journal ArticleDOI
Protein Posttranslational Modifications: Roles in Aging and Age-Related Disease.
Ana L. Santos,Ariel B. Lindner +1 more
TL;DR: An overview of the interplay of PTMs in aging-associated molecular processes in eukaryotic aging models is presented, revealing the potential of simple prokaryotic models to uncover complex aging- associated molecular processes on the emerging field of microbiogerontology.
Journal ArticleDOI
Distinct profiles of REST interactions with its target genes at different stages of neuronal development.
Yuh-Man Sun,Deborah J. Greenway,Rory Johnson,Miyoko Street,Nikolai D. Belyaev,Jim Deuchars,Thomas Bee,Sandra Wilde,Noel J. Buckley +8 more
TL;DR: Data indicate that the REST regulon is specific to each developmental stage and support the notion that REST plays distinct roles in regulating gene expression in pluripotent ES cells, multipotent NS cells, and mature neurons.
References
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Journal ArticleDOI
Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
Journal ArticleDOI
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Ru Cao,Liangjun Wang,Hengbin Wang,Li Xia,Hediye Erdjument-Bromage,Paul Tempst,Richard S. Jones,Yi Zhang +7 more
TL;DR: The purification and characterization of an EED-EZH2 complex, the human counterpart of the Drosophila ESC-E(Z) complex, is reported, and it is demonstrated that the complex specifically methylates nucleosomal histone H3 at lysine 27 (H3-K27).
Journal ArticleDOI
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
TL;DR: It is shown that mammalian methyltransferases that selectively methylate histone H3 on lysine 9 (Suv39h HMTases) generate a binding site for HP1 proteins—a family of heterochromatic adaptor molecules implicated in both gene silencing and supra-nucleosomal chromatin structure.
Journal ArticleDOI
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.
Andrew J. Bannister,Philip Zegerman,Janet F. Partridge,Eric A. Miska,Jean O. Thomas,Robin C. Allshire,Tony Kouzarides +6 more
TL;DR: A stepwise model for the formation of a transcriptionally silent heterochromatin is provided: SUV39H1 places a ‘methyl marker’ on histone H3, which is then recognized by HP1 through its chromo domain, which may also explain the stable inheritance of theheterochromatic state.
Journal ArticleDOI
Regulation of chromatin structure by site-specific histone H3 methyltransferases
Stephen Rea,Frank Eisenhaber,Dónal O'Carroll,Brian D. Strahl,Zu-Wen Sun,Manfred Schmid,Susanne Opravil,Karl Mechtler,Chris P. Ponting,C D Allis,Thomas Jenuwein +10 more
TL;DR: A functional interdependence of site-specific H3 tail modifications is revealed and a dynamic mechanism for the regulation of higher-order chromatin is suggested.