PatentDOI
Histone demethylation mediated by the nuclear amine oxidase homolog lsd1
Yang Shi,Yujiang Shi +1 more
TLDR
In this paper, the authors identify a histone demethylase conserved from S. pombe to human and reveal dynamic regulation of histone methylation by both histonemethylases and demethylases.About:
This article is published in Cell.The article was published on 2005-12-16. It has received 3281 citations till now. The article focuses on the topics: Histone lysine demethylation & Histone demethylation.read more
Citations
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Journal ArticleDOI
Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer
Qianben Wang,Wei Li,Yong Zhang,Xin Yuan,Kexin Xu,Jindan Yu,Zhong Chen,Rameen Beroukhim,Rameen Beroukhim,Hongyun Wang,Mathieu Lupien,Tao Wu,Meredith M. Regan,Clifford A. Meyer,Jason S. Carroll,Arjun K. Manrai,Olli A. Jänne,Steven P. Balk,Rohit Mehra,Bo Han,Arul M. Chinnaiyan,Mark A. Rubin,Lawrence D. True,Michelangelo Fiorentino,Christopher Fiore,Massimo Loda,Philip W. Kantoff,X. Shirley Liu,Myles Brown +28 more
TL;DR: The role of AR in androgen-independent cancer cells is not to direct the androgen -dependent gene expression program without androgen, but rather to execute a distinct program resulting in androgens-independent growth.
Journal ArticleDOI
Regulation of histone methylation by demethylimination and demethylation.
Robert J. Klose,Yi Zhang +1 more
TL;DR: The enzymatic and structural basis for the mechanisms that these enzymes use to counteract histone methylation are examined and insights into their substrate specificity and biological function are provided.
Journal ArticleDOI
Targeting the cancer epigenome for therapy
TL;DR: As epigenetic drugs target the epigenome as a whole, these true 'genomic medicines' lessen the need for precision approaches to individualized therapies.
Journal ArticleDOI
Regulation of LSD1 histone demethylase activity by its associated factors.
TL;DR: It is shown that CoREST endows LSD1 with the ability to demethylate nucleosomal substrates and that it protects LSD1 from proteasomal degradation in vivo, suggesting that hypoacetylated nucleosomes may be the preferred physiological substrate.
Journal ArticleDOI
Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes
Mark D.M. Leiserson,Fabio Vandin,Hsin-Ta Wu,Jason R. Dobson,Jonathan V. Eldridge,Jacob L. Thomas,Alexandra Papoutsaki,Younhun Kim,Beifang Niu,Michael D. McLellan,Michael S. Lawrence,Abel Gonzalez-Perez,David Tamborero,Yuwei Cheng,Gregory A. Ryslik,Nuria Lopez-Bigas,Gad Getz,Li Ding,Benjamin J. Raphael +18 more
TL;DR: A pan-cancer analysis of mutated networks in 3,281 samples from 12 cancer types from The Cancer Genome Atlas is performed using HotNet2, a new algorithm to find mutated subnetworks that overcomes the limitations of existing single-gene, pathway and network approaches.
References
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Journal ArticleDOI
Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
Journal ArticleDOI
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Ru Cao,Liangjun Wang,Hengbin Wang,Li Xia,Hediye Erdjument-Bromage,Paul Tempst,Richard S. Jones,Yi Zhang +7 more
TL;DR: The purification and characterization of an EED-EZH2 complex, the human counterpart of the Drosophila ESC-E(Z) complex, is reported, and it is demonstrated that the complex specifically methylates nucleosomal histone H3 at lysine 27 (H3-K27).
Journal ArticleDOI
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
TL;DR: It is shown that mammalian methyltransferases that selectively methylate histone H3 on lysine 9 (Suv39h HMTases) generate a binding site for HP1 proteins—a family of heterochromatic adaptor molecules implicated in both gene silencing and supra-nucleosomal chromatin structure.
Journal ArticleDOI
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.
Andrew J. Bannister,Philip Zegerman,Janet F. Partridge,Eric A. Miska,Jean O. Thomas,Robin C. Allshire,Tony Kouzarides +6 more
TL;DR: A stepwise model for the formation of a transcriptionally silent heterochromatin is provided: SUV39H1 places a ‘methyl marker’ on histone H3, which is then recognized by HP1 through its chromo domain, which may also explain the stable inheritance of theheterochromatic state.
Journal ArticleDOI
Regulation of chromatin structure by site-specific histone H3 methyltransferases
Stephen Rea,Frank Eisenhaber,Dónal O'Carroll,Brian D. Strahl,Zu-Wen Sun,Manfred Schmid,Susanne Opravil,Karl Mechtler,Chris P. Ponting,C D Allis,Thomas Jenuwein +10 more
TL;DR: A functional interdependence of site-specific H3 tail modifications is revealed and a dynamic mechanism for the regulation of higher-order chromatin is suggested.