PatentDOI
Histone demethylation mediated by the nuclear amine oxidase homolog lsd1
Yang Shi,Yujiang Shi +1 more
TLDR
In this paper, the authors identify a histone demethylase conserved from S. pombe to human and reveal dynamic regulation of histone methylation by both histonemethylases and demethylases.About:
This article is published in Cell.The article was published on 2005-12-16. It has received 3281 citations till now. The article focuses on the topics: Histone lysine demethylation & Histone demethylation.read more
Citations
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Journal ArticleDOI
Chromatin Modifications and Their Function
TL;DR: The surface of nucleosomes is studded with a multiplicity of modifications that can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA.
Journal ArticleDOI
Regulation of chromatin by histone modifications
TL;DR: The known histone modifications are described, where they are found genomically and discussed and some of their functional consequences are discussed, concentrating mostly on transcription where the majority of characterisation has taken place.
Journal ArticleDOI
Epigenetics in Cancer
TL;DR: The current understanding of alterations in the epigenetic landscape that occur in cancer compared with normal cells, the roles of these changes in cancer initiation and progression, including the cancer stem cell model, and the potential use of this knowledge in designing more effective treatment strategies are discussed.
Journal ArticleDOI
The Emerging Hallmarks of Cancer Metabolism
TL;DR: This Perspective has organized known cancer-associated metabolic changes into six hallmarks: deregulated uptake of glucose and amino acids, use of opportunistic modes of nutrient acquisition, useof glycolysis/TCA cycle intermediates for biosynthesis and NADPH production, increased demand for nitrogen, alterations in metabolite-driven gene regulation, and metabolic interactions with the microenvironment.
Journal ArticleDOI
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
Miao-Chih Tsai,Ohad Manor,Yue Wan,Nima Mosammaparast,Jordon K. Wang,Fei Lan,Yang Shi,Eran Segal,Howard Y. Chang +8 more
TL;DR: The results suggest that lincRNAs may serve as scaffolds by providing binding surfaces to assemble select histone modification enzymes, thereby specifying the pattern of histone modifications on target genes.
References
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Journal ArticleDOI
JHDM2A, a JmjC-Containing H3K9 Demethylase, Facilitates Transcription Activation by Androgen Receptor
Kenichi Yamane,Charalambos Toumazou,Yu Ichi Tsukada,Hediye Erdjument-Bromage,Paul Tempst,Jiemin Wong,Yi Zhang +6 more
TL;DR: This work identifies a histone demethylase and links its function to hormone-dependent transcriptional activation, resulting in H3K9 demethylation and transcriptionalactivation.
Journal ArticleDOI
Histone H3 lysine 4 methylation patterns in higher eukaryotic genes.
Robert Schneider,Andrew J. Bannister,Fiona A. Myers,Alan W. Thorne,Colyn Crane-Robinson,Tony Kouzarides +5 more
TL;DR: The results indicate that in metazoa, di- and tri-methylation of K4/H3 is linked to active transcription and that significant differences exist in the genome-wide methylation pattern as compared with S. cerevisiae.
Journal ArticleDOI
Coordinated histone modifications mediated by a CtBP co-repressor complex
Yujiang Shi,Jun-ichi Sawada,Guangchao Sui,El Bachir Affar,Johnathan R. Whetstine,Fei Lan,Hidesato Ogawa,Margaret Po-Shan Luke,Yoshihiro Nakatani,Yang Shi +9 more
TL;DR: The identification of a CtBP complex that contains the essential components for both gene targeting and coordinated histone modifications, allowing for the effective repression of genes targeted by CtBP is reported.
Journal ArticleDOI
Transitions in Distinct Histone H3 Methylation Patterns at the Heterochromatin Domain Boundaries
TL;DR: It is shown that distinct site-specific histone H3 methylation patterns define euchromatic and heterochromatic chromosomal domains within a 47-kilobase region of the mating-type locus in fission yeast.
Journal ArticleDOI
The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation.
Nevan J. Krogan,Jim Dover,Adam Wood,Jessica Schneider,Jonathan Heidt,Marry Ann Boateng,Kimberly Dean,Owen Ryan,Ashkan Golshani,Mark Johnston,Jack Greenblatt,Ali Shilatifard +11 more
TL;DR: It is reported that the Paf1 protein complex, which is associated with the elongating RNA polymerase II, is required for methylation of lysines 4 and 79 of histone H3 and for silencing of expression of a telomere-associated gene.