PatentDOI
Histone demethylation mediated by the nuclear amine oxidase homolog lsd1
Yang Shi,Yujiang Shi +1 more
TLDR
In this paper, the authors identify a histone demethylase conserved from S. pombe to human and reveal dynamic regulation of histone methylation by both histonemethylases and demethylases.About:
This article is published in Cell.The article was published on 2005-12-16. It has received 3281 citations till now. The article focuses on the topics: Histone lysine demethylation & Histone demethylation.read more
Citations
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Journal ArticleDOI
KDM5C Is Overexpressed in Prostate Cancer and Is a Prognostic Marker for Prostate-Specific Antigen-Relapse Following Radical Prostatectomy
Johannes Stein,Michael Majores,Magdalena Rohde,Soyoung Lim,Simon Schneider,Eliana Krappe,Jörg Ellinger,Manfred Dietel,Carsten Stephan,Klaus Jung,Sven Perner,Glen Kristiansen,Jutta Kirfel +12 more
TL;DR: The data indicate that KDM5C is functionally involved in proliferation control of prostate cancer cells and might represent a novel attractive therapy target and overexpression of KDM 5C is an independent new predictive marker for therapy failure as determined by biochemical recurrence in patients after prostatectomy.
Journal ArticleDOI
KDM2B is a histone H3K79 demethylase and induces transcriptional repression via sirtuin-1-mediated chromatin silencing.
Joo-Young Kang,Ji-Young Kim,Kee-Beom Kim,Jin Woo Park,Hana Cho,Ja Young Hahm,Yun-Cheol Chae,Dae Hwan Kim,Hyun Kook,Sangmyung Rhee,Nam-Chul Ha,Sang-Beom Seo +11 more
TL;DR: It is shown that KDM2B, also known as FBXL10 and a member of the Jumonji C family of proteins known for its histone H3K36 demethylase activity, is a di‐ and trimethyl H3k79 dem methylase and induces transcriptional repression via sirtuin‐1‐mediated chromatin silencing.
Journal ArticleDOI
FOXP3 Orchestrates H4K16 Acetylation and H3K4 Trimethylation for Activation of Multiple Genes by Recruiting MOF and Causing Displacement of PLU-1
Hiroto Katoh,Zhaohui S. Qin,Runhua Liu,Lizhong Wang,Weiquan Li,Xiangzhi Li,Lipeng Wu,Zhanwen Du,Robert H. Lyons,Chang Gong Liu,Xiuping Liu,Yali Dou,Pan Zheng,Yang Liu +13 more
TL;DR: The data demonstrate a pull-push model in which a single transcription factor orchestrates two epigenetic alterations necessary for gene activation and provide a mechanism for somatic inactivation of the FOXP3 protein function in cancer cells.
Journal ArticleDOI
Natural products as LSD1 inhibitors for cancer therapy.
TL;DR: This review discusses the identification of natural LSD1 inhibitors, analysis of the co-crystal structures of LSD1/natural product complex, antitumor activity and their modes of action, and briefly discusses the challenges faced in this field.
Journal ArticleDOI
Chromatin-modifying enzymes as therapeutic targets--Part 1.
TL;DR: A review of the roles of chromatin-modifying enzymes in gene regulation and their potentials as therapeutic targets for epigenetic therapies is focused on enzymes responsible for histone acetylation, deacetylation and demethylation.
References
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Journal ArticleDOI
Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
Journal ArticleDOI
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Ru Cao,Liangjun Wang,Hengbin Wang,Li Xia,Hediye Erdjument-Bromage,Paul Tempst,Richard S. Jones,Yi Zhang +7 more
TL;DR: The purification and characterization of an EED-EZH2 complex, the human counterpart of the Drosophila ESC-E(Z) complex, is reported, and it is demonstrated that the complex specifically methylates nucleosomal histone H3 at lysine 27 (H3-K27).
Journal ArticleDOI
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
TL;DR: It is shown that mammalian methyltransferases that selectively methylate histone H3 on lysine 9 (Suv39h HMTases) generate a binding site for HP1 proteins—a family of heterochromatic adaptor molecules implicated in both gene silencing and supra-nucleosomal chromatin structure.
Journal ArticleDOI
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.
Andrew J. Bannister,Philip Zegerman,Janet F. Partridge,Eric A. Miska,Jean O. Thomas,Robin C. Allshire,Tony Kouzarides +6 more
TL;DR: A stepwise model for the formation of a transcriptionally silent heterochromatin is provided: SUV39H1 places a ‘methyl marker’ on histone H3, which is then recognized by HP1 through its chromo domain, which may also explain the stable inheritance of theheterochromatic state.
Journal ArticleDOI
Regulation of chromatin structure by site-specific histone H3 methyltransferases
Stephen Rea,Frank Eisenhaber,Dónal O'Carroll,Brian D. Strahl,Zu-Wen Sun,Manfred Schmid,Susanne Opravil,Karl Mechtler,Chris P. Ponting,C D Allis,Thomas Jenuwein +10 more
TL;DR: A functional interdependence of site-specific H3 tail modifications is revealed and a dynamic mechanism for the regulation of higher-order chromatin is suggested.