Hsp90, the concertmaster: tuning transcription.
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TLDR
The role of Hsp90 is discussed in all the three aforementioned mechanisms of transcriptional control, taking examples from various model organisms with a special emphasis on cancer progression.Abstract:
In the last decade Hsp90 has emerged as a major regulator of cancer cell growth and proliferation In cancer cells, it assists in giving maturation to oncogenic proteins including several kinases and transcription factors Recent studies have shown that apart from its chaperone activity, it also imparts regulation of transcription machinery and thereby alters the cellular physiology Hsp90 and its co-chaperones modulate transcription at-least at three different levels In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues Secondly, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment Thirdly, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression In this review, we discuss the role of Hsp90 in all the three aforementioned mechanisms of transcriptional control, taking examples from various model organisms with a special emphasis on cancer progressionread more
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The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
Mehdi Bouhaddou,Danish Memon,Bjoern Meyer,Kris M. White,Veronica V. Rezelj,Miguel Correa Marrero,Benjamin J. Polacco,James E. Melnyk,Svenja Ulferts,Robyn M. Kaake,Jyoti Batra,Alicia L. Richards,Erica Stevenson,David E. Gordon,Ajda Rojc,Kirsten Obernier,Jacqueline M. Fabius,Margaret Soucheray,Lisa Miorin,Elena Moreno,Cassandra Koh,Quang Dinh Tran,Alexandra Hardy,Rémy Robinot,Thomas Vallet,Benjamin E. Nilsson-Payant,Claudia Hernandez-Armenta,Alistair Dunham,Sebastian Weigang,Julian Knerr,Maya Modak,Diego Quintero,Yuan Zhou,Aurelien Dugourd,Alberto Valdeolivas,Trupti Patil,Qiongyu Li,Ruth Hüttenhain,Merve Cakir,Monita Muralidharan,Minkyu Kim,Gwendolyn M. Jang,Beril Tutuncuoglu,Joseph Hiatt,Jeffrey Z. Guo,Jiewei Xu,Sophia Bouhaddou,Christopher J.P. Mathy,Anna Gaulton,Emma J. Manners,Eloy Felix,Ying Shi,Marisa Goff,Jean K. Lim,Timothy McBride,Michael C. O’Neal,Yiming Cai,Jason C.J. Chang,David J. Broadhurst,Saker Klippsten,Emmie de Wit,Andrew R. Leach,Tanja Kortemme,Brian K. Shoichet,Melanie Ott,Julio Saez-Rodriguez,Benjamin R. tenOever,R. Dyche Mullins,Elizabeth R. Fischer,Georg Kochs,Robert Grosse,Adolfo García-Sastre,Marco Vignuzzi,Jeffery R. Johnson,Kevan M. Shokat,Danielle L. Swaney,Pedro Beltrao,Nevan J. Krogan +77 more
TL;DR: A quantitative mass spectrometry-based phosphoproteomics survey of SARS-CoV-2 infection in Vero E6 cells reveals dramatic rewiring of phosphorylation on host and viral proteins, revealing potential COVID-19 therapies.
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Increased protein stability causes DNA methyltransferase 1 dysregulation in breast cancer. Vol. 280 (2005) 18302-18310
Agoston T. Agoston,Pedram Argani,Srinivasan Yegnasubramanian,Angelo M. De Marzo,Mohammad Ali Ansari-Lari,Jessica Hicks,Nancy E. Davidson,William G. Nelson +7 more
TL;DR: In this article, DNA methyltransferase 1 (DNMT1) expression is dysregulated in breast cancer without a concomitant increase in DNMT1 mRNA or proliferative fraction.
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Adapting to stress - chaperome networks in cancer.
TL;DR: It is argued that in cancer cells, a state of chaperomes hyperconnectivity is obtained by increasing the interaction strength among chaperome machinery members, and this concept will change how drugs targeting the chaperite to treat cancer are developed and implemented.
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LSD1 engages a corepressor complex for the activation of the estrogen receptor α by estrogen and cAMP
TL;DR: The estrogen receptor α (ERα) is a transcription factor that can be directly activated by estrogen or indirectly by other signaling pathways as mentioned in this paper, and activation of the unliganded ERα by cAMP is mediated by phosphorylation of the transcriptional coactivator CARM1 by protein kinase A (PKA).
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HSP90 Chaperoning in Addition to Phosphoprotein Required for Folding but Not for Supporting Enzymatic Activities of Measles and Nipah Virus L Polymerases
Louis Marie Bloyet,Jeremy Charles Welsch,François Enchéry,Cyrille Mathieu,Sylvain de Breyne,Branka Horvat,Boyan Grigorov,Denis Gerlier +7 more
TL;DR: It is found that efficient chaperoning of L by HSP90 requires P in the measles, Nipah, and vesicular stomatitis viruses, a new paradigm for the maturation of a viral polymerase appears to be conserved in several members of the Mononegavirales order.
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