Mapping brain circuitry with a light microscope.
TLDR
An overview of the present state and future opportunities in charting long-range and local connectivity in the entire mouse brain and in linking brain circuits to function is presented.Abstract:
The beginning of the 21st century has seen a renaissance in light microscopy and anatomical tract tracing that together are rapidly advancing our understanding of the form and function of neuronal circuits. The introduction of instruments for automated imaging of whole mouse brains, new cell type–specific and trans-synaptic tracers, and computational methods for handling the whole-brain data sets has opened the door to neuroanatomical studies at an unprecedented scale. We present an overview of the present state and future opportunities in charting long-range and local connectivity in the entire mouse brain and in linking brain circuits to function.read more
Citations
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CLARITY for mapping the nervous system
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Neural Networks of the Mouse Neocortex
Brian Zingg,Houri Hintiryan,Lin Gou,Monica Y. Song,Maxwell Bay,Michael S. Bienkowski,Nicholas N. Foster,Seita Yamashita,Ian Bowman,Arthur W. Toga,Hong-Wei Dong +10 more
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Advanced CUBIC protocols for whole-brain and whole-body clearing and imaging.
Etsuo A. Susaki,Etsuo A. Susaki,Etsuo A. Susaki,Kazuki Tainaka,Kazuki Tainaka,Kazuki Tainaka,Dimitri Perrin,Hiroko Yukinaga,Akihiro Kuno,Hiroki R. Ueda,Hiroki R. Ueda,Hiroki R. Ueda +11 more
TL;DR: A protocol for advanced CUBIC (Clear, Unobstructed Brain/Body Imaging Cocktails and Computational analysis) is described in this paper, which enables simple and efficient organ clearing, rapid imaging by light-sheet microscopy and quantitative imaging analysis of multiple samples.
PatentDOI
Transparent, flexible, low-noise graphene electrodes for simultaneous electrophysiology and neuro-imaging
TL;DR: A transparent, flexible neural electrode technology based on graphene is reported, which enables simultaneous optical imaging and electrophysiological recording and may pave the way for high spatio-temporal resolution electro-optic mapping of the dynamic neuronal activity.
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A Whole-Brain Atlas of Inputs to Serotonergic Neurons of the Dorsal and Median Raphe Nuclei
Iskra Pollak Dorocic,Daniel Fürth,Yang Xuan,Yvonne Johansson,Laura Pozzi,Gilad Silberberg,Marie Carlén,Konstantinos Meletis +7 more
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References
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Monosynaptic Restriction of Transsynaptic Tracing from Single, Genetically Targeted Neurons
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