Meta-analysis identifies six new susceptibility loci for atrial fibrillation
Patrick T. Ellinor,Kathryn L. Lunetta,Christine M. Albert,Christine M. Albert,Nicole L. Glazer,Marylyn D. Ritchie,Albert V. Smith,Dan E. Arking,Martina Müller-Nurasyid,Bouwe P. Krijthe,Steven A. Lubitz,Steven A. Lubitz,Joshua C. Bis,Mina K. Chung,Mina K. Chung,Marcus Dörr,Kouichi Ozaki,Jason D. Roberts,J. Gustav Smith,J. Gustav Smith,Arne Pfeufer,Moritz F. Sinner,Moritz F. Sinner,Moritz F. Sinner,Kurt Lohman,Jingzhong Ding,Nicholas L. Smith,Jonathan D. Smith,Jonathan D. Smith,Michiel Rienstra,Kenneth Rice,David R. Van Wagoner,David R. Van Wagoner,Jared W. Magnani,Reza Wakili,Sebastian Clauss,Jerome I. Rotter,Gerhard Steinbeck,Lenore J. Launer,Robert W. Davies,Matthew Borkovich,Tamara B. Harris,Honghuang Lin,Uwe Völker,Henry Völzke,David J. Milan,Albert Hofman,Eric Boerwinkle,Lin Y. Chen,Elsayed Z. Soliman,Benjamin F. Voight,Guo Li,Aravinda Chakravarti,Michiaki Kubo,Usha B. Tedrow,Usha B. Tedrow,Lynda M. Rose,Paul M. Ridker,Paul M. Ridker,David Conen,Tatsuhiko Tsunoda,Tetsushi Furukawa,Nona Sotoodehnia,Siyan Xu,Naoyuki Kamatani,Daniel Levy,Yusuke Nakamura,Babar Parvez,Saagar Mahida,Karen L. Furie,Jonathan Rosand,Raafia Muhammad,Bruce M. Psaty,Thomas Meitinger,Siegfried Perz,H-Erich Wichmann,Jacqueline C.M. Witteman,W. H. Linda Kao,Sekar Kathiresan,Sekar Kathiresan,Dan M. Roden,André G. Uitterlinden,Fernando Rivadeneira,Barbara McKnight,Marketa Sjögren,Anne B. Newman,Yongmei Liu,Michael H. Gollob,Olle Melander,Toshihiro Tanaka,Bruno H. Stricker,Stephan B. Felix,Alvaro Alonso,Dawood Darbar,John Barnard,Daniel I. Chasman,Daniel I. Chasman,Susan R. Heckbert,Susan R. Heckbert,Emelia J. Benjamin,Vilmundur Gudnason,Stefan Kääb +101 more
TLDR
Six new atrial fibrillation susceptibility loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules that are associated with stroke, heart failure and death.Abstract:
Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death. We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 10,030 subjects without atrial fibrillation (P < 5 × 10(-8)). Four of the loci identified in Europeans were further replicated in silico in a GWAS of Japanese individuals, including 843 individuals with and 3,350 individuals without atrial fibrillation. The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules.read more
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Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association
Emelia J. Benjamin,Michael J. Blaha,Stephanie E. Chiuve,Mary Cushman,Sandeep R Das,Rajat Deo,Sarah D. de Ferranti,James S. Floyd,Myriam Fornage,Cathleen Gillespie,Carmen R. Isasi,Monik C. Jim'nez,Lori Chaffn Jordan,Suzanne E. Judd,Daniel T. Lackland,Judith H. Lichtman,Lynda D. Lisabeth,Simin Liu,Chris T. Longenecker,Rachel H. Mackey,Kunihiro Matsushita,Dariush Mozaffarian,Michael E. Mussolino,Khurram Nasir,Robert W. Neumar,Latha Palaniappan,Dilip K. Pandey,Ravi R. Thiagarajan,Mathew J. Reeves,Matthew D. Ritchey,Carlos J. Rodriguez,Gregory A. Roth,Wayne D. Rosamond,Comilla Sasson,Amytis Towfghi,Connie W. Tsao,Melanie B. Turner,Salim S. Virani,Jenifer H. Voeks,Joshua Z. Willey,John T. Wilkins,Jason H Y Wu,Heather M. Alger,Sally S. Wong,Paul Muntner +44 more
TL;DR: WRITING GROUP MEMBERS Emelia J. Benjamin, MD, SCM, FAHA Michael J. Reeves, PhD Matthew Ritchey, PT, DPT, OCS, MPH Carlos J. Jiménez, ScD, SM Lori Chaffin Jordan,MD, PhD Suzanne E. Judd, PhD
Journal ArticleDOI
2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society
Craig T. January,L. Samuel Wann,Joseph S. Alpert,Hugh Calkins,Joaquin E. Cigarroa,Joseph C. Cleveland,Jamie B. Conti,Patrick T. Ellinor,Michael D. Ezekowitz,Michael E. Field,Katherine T. Murray,Ralph L. Sacco,William G. Stevenson,Patrick J. Tchou,Cynthia M. Tracy,Clyde W. Yancy +15 more
TL;DR: This document summarizes current research, plans, and recommendations for future research, as well as providing a history of the field and some of the techniques used, currently in use, at the National Institutes of Health.
Journal ArticleDOI
Heart Disease and Stroke Statistics—2016 Update: A Report From the American Heart Association
Dariush Mozaffarian,Emelia J. Benjamin,Alan S. Go,Donna K. Arnett,Michael J. Blaha,Mary Cushman,Sandeep R Das,Sarah D. de Ferranti,Jean-Pierre Després,Heather J. Fullerton,Virginia J. Howard,Mark D. Huffman,Carmen R. Isasi,Monik C. Jiménez,Suzanne E. Judd,Brett M. Kissela,Judith H. Lichtman,Lynda D. Lisabeth,Simin Liu,Rachel H. Mackey,David J. Magid,Darren K. McGuire,Emile R. Mohler,Claudia S. Moy,Paul Muntner,Michael E. Mussolino,Khurram Nasir,Robert W. Neumar,Graham Nichol,Latha Palaniappan,Dilip K. Pandey,Mathew J. Reeves,Carlos J. Rodriguez,Wayne D. Rosamond,Paul D. Sorlie,Joel M. Stein,Amytis Towfighi,Tanya N. Turan,Salim S. Virani,Daniel Woo,Robert W. Yeh,Melanie B. Turner +41 more
TL;DR: Author(s): Writing Group Members; Mozaffarian, Dariush; Benjamin, Emelia J; Go, Alan S; Arnett, Donna K; Blaha, Michael J; Cushman, Mary; Das, Sandeep R; de Ferranti, Sarah; Despres, Jean-Pierre; Fullerton, Heather J; Howard, Virginia J; Huffman, Mark D; Isasi, Carmen R; Jimenez, Monik C; Judd, Suzanne
Journal ArticleDOI
Heart Disease and Stroke Statistics—2013 Update A Report From the American Heart Association
Alan S. Go,Dariush Mozaffarian,Véronique L. Roger,Emelia J. Benjamin,Jarett D. Berry,William B. Borden,Dawn M. Bravata,Shifan Dai,Earl S. Ford,Caroline S. Fox,Sheila Franco,Heather J. Fullerton,Cathleen Gillespie,Susan M. Hailpern,John A. Heit,Virginia J. Howard,Mark D. Huffman,Brett M. Kissela,Steven J. Kittner,Daniel T. Lackland,Judith H. Lichtman,Lynda D. Lisabeth,David J. Magid,Gregory M. Marcus,Ariane Marelli,David B. Matchar,Darren K. McGuire,Emile R. Mohler,Claudia S. Moy,Michael E. Mussolino,Graham Nichol,Nina P. Paynter,Pamela J. Schreiner,Paul D. Sorlie,Joel Stein,Tanya N. Turan,Salim S. Virani,Nathan D. Wong,Daniel Woo,Melanie B. Turner +39 more
TL;DR: Author(s): Go, Alan S; Mozaffarian, Dariush; Roger, Veronique L; Benjamin, Emelia J; Berry, Jarett D; Borden, William B; Bravata, Dawn M; Dai, Shifan; Ford, Earl S; Fox, Caroline S; Franco, Sheila; Fullerton, Heather J; Gillespie, Cathleen; Hailpern, Susan M; Heit, John A; Howard, Virginia J; Huff
Journal ArticleDOI
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Paulus Kirchhof,Stefano Benussi,Dipak Kotecha,Anders Ahlsson,Dan Atar,Barbara Casadei,Manuel Castellá,Hans-Christoph Diener,Hein Heidbuchel,Jeroen M.L. Hendriks,Gerhard Hindricks,Antonis S. Manolis,Jonas Oldgren,Bogdan A. Popescu,Ulrich Schotten,Bart P. Van Putte,Panagiotis Vardas,Stefan Agewall,John Camm,Gonzalo Barón Esquivias,Werner Budts,Scipione Carerj,Filip Casselman,Antonio Coca,Raffaele De Caterina,Spiridon Deftereos,Dobromir Dobrev,José M. Ferro,Gerasimos Filippatos,Donna Fitzsimons,Bulent Gorenek,Maxine Guenoun,Stefan H. Hohnloser,Philippe Kolh,Gregory Y.H. Lip,Athanasios J. Manolis,John J.V. McMurray,Piotr Ponikowski,Raphael Rosenhek,Frank Ruschitzka,Irina Savelieva,Sanjay Sharma,Piotr Suwalski,Juan Tamargo,Clare J Taylor,Isabelle C. Van Gelder,Adriaan A. Voors,Stephan Windecker,José Luis Zamorano,Katja Zeppenfeld +49 more
TL;DR: The Task Force for the management of atrial fibrillation of the European Society of Cardiology has been endorsed by the European Stroke Organisation (ESO).
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