Journal ArticleDOI
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Michael M. Crowley,Feng Zhang,Michael A. Repka,Sridhar Thumma,Sampada B. Upadhye,Sunil Kumar Battu,James W. McGinity,Charles R. Martin +7 more
TLDR
The pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology, are reviewed and the physicochemical properties of the resultant dosage forms are described.Abstract:
Interest in hot-melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicochemical properties of the resultant dosage forms are described. Part II of this review will focus on various applications of HME in drug delivery such as granules, pellets, immediate and modified release tablets, transmucosal and transdermal systems, and implants.read more
Citations
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Foaming of amorphous drug delivery systems prepared by hot melt mixing and extrusion
TL;DR: In this article, Terife et al. used the Hot Melt Extrusion (HME) process to compound the following API/polymer binary systems: Indomethacin (INM) with Soluplus® (PVCap-PVAc-PEG); Carbamazepine (CBZ) with PVCap-pVAc)-PEG; and INM with Eudragit® EPO.
Dissertation
Development of lipid matrix tablets containing a double fixed dose combination of artemisone and lumefantrine
TL;DR: Artemisone, an artemisinin derivative, signifies a new class of antimalarial drugs that is an effective blood schizontocide against strains of drug-resistant Plasmodium falciparum malaria and Lumefantrine was chosen as the long acting drug that has poor aqueous solubility, is highly lipophilic and depicts erratic absorption, leading to poor bioavailability.
Dissertation
Polymer-bile salts interaction and its impact on the solubilisation and intestinal uptake of poorly water-soluble drugs
TL;DR: The author thanks her family, her outstanding parents for their love, their encouragement and support, and all the friends that have been part of her life in Norwich, for the happy times together and for being supportive when she mostly needed.
Journal ArticleDOI
Investigation of the Fused Deposition Modeling Additive Manufacturing I: Influence of Process Temperature on the Quality and Crystallinity of the Dosage Forms.
TL;DR: In this article, a series of comparative studies, including morphology, solid-state analysis, and in vitro drug release studies between additive manufactured filaments (printlets) and extruded filaments, were conducted.
Journal ArticleDOI
Development of an algorithm to identify mass production candidate molecules to develop children’s oral medicines: a North American perspective
Varsha Bhatt-Mehta,Robert B. MacArthur,Raimar Löbenberg,Jeffrey J. Cies,Ibolja Cernak,Richard H. Parrish +5 more
TL;DR: A group of clinicians and scientists with a common interest in pediatric drug development and medicines-use systems developed a practical framework for identifying a list of active pharmaceutical ingredients (APIs) with the greatest market potential for development to use in pediatric patients.
References
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Journal ArticleDOI
Pharmaceutical Applications of Solid Dispersion Systems
Win Loung Chiou,Sidney Riegelman +1 more
Book
Polymer Science and Technology
TL;DR: The authors provided the basic building blocks of polymer science and engineering by coverage of fundamental polymer chemistry and materials topics given in Chapters 1 through 7 and provided information on the exciting new materialsnow available and the emerging areas of technological growth that could motivate a new generation of scientists and engineers.
Journal ArticleDOI
Spectroscopic characterization of interactions between PVP and indomethacin in amorphous molecular dispersions.
Lynne S. Taylor,George Zografi +1 more
TL;DR: A comparison of the carbonyl stretching region of γ indomethacin, known to form carboxylic acid dimers, with that of amorphous indometHacin indicated that the amorphously phase exists predominantly as dimers.
Book
Principles of polymer engineering
TL;DR: In this article, the elastic properties of polymeric solids and their properties of rubber are discussed. But they focus on the structure of the molecule rather than the properties of the solids.
Journal ArticleDOI
Melt extrusion: from process to drug delivery technology
TL;DR: Improved bioavailability was achieved again demonstrating the value of the technology as a drug delivery tool, with particular advantages over solvent processes like co-precipitation.