Journal ArticleDOI
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Michael M. Crowley,Feng Zhang,Michael A. Repka,Sridhar Thumma,Sampada B. Upadhye,Sunil Kumar Battu,James W. McGinity,Charles R. Martin +7 more
TLDR
The pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology, are reviewed and the physicochemical properties of the resultant dosage forms are described.Abstract:
Interest in hot-melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicochemical properties of the resultant dosage forms are described. Part II of this review will focus on various applications of HME in drug delivery such as granules, pellets, immediate and modified release tablets, transmucosal and transdermal systems, and implants.read more
Citations
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Journal ArticleDOI
Evaluation of the recrystallization kinetics of hot-melt extruded polymeric solid dispersions using an improved Avrami equation
Xin Feng,Xingyou Ye,Jun-Bom Park,Wenli Lu,Joseph T. Morott,Brad Beissner,Zhuoyang Lian,Elanor Pinto,Vivian Bi,Stu Porter,Thomas Durig,Soumyajit Majumdar,Michael A. Repka +12 more
TL;DR: An improved kinetic model was used to evaluate the recrystallization kinetics of amorphous structures and to further understand the factors influencing the physical stability of am Morphous solid dispersions.
Journal ArticleDOI
Evaluation of the bioavailability of hydrocortisone when prepared as solid dispersion
Mohammad A. Altamimi,Ehab M. Elzayat,Wajhul Qamar,Sultan Alshehri,Abdelrahman Y Sherif,Nazrul Haq,Faiyaz Shakeel +6 more
TL;DR: Formation of new chemical bonds in the formed particle was suggested due to the change in the vibrational wave numbers and the significant improvement in the bioavailability of the dispersed particles proved the importance of this technique.
Journal ArticleDOI
Melt Extrusion of High-Dose Co-Amorphous Drug-Drug Combinations : Theme: Formulation and Manufacturing of Solid Dosage Forms Guest Editors: Tony Zhou and Tonglei Li.
Lærke Arnfast,Kamruzzaman,Korbinian Löbmann,Johanna Aho,Stefania Baldursdottir,Thomas Rades,Thomas Rades,Jukka Rantanen +7 more
TL;DR: Melt extrusion of co-amorphous extrudates with low amounts of polymer was found to be a feasible manufacturing technique and display viscosities higher than expected for small molecule melts and addition of PEO decreased the viscosity of the melt.
Dissertation
Hot-melt extrusion with poorly soluble drugs
TL;DR: In this article, the authors proposed to use basic butylated methacrylate copolymer as a carrier to enhance the solubility of poorly water-soluble drugs in a hot-melt extrusion process.
Journal ArticleDOI
Melt extrusion vs. spray drying: The effect of processing methods on crystalline content of naproxen-povidone formulations.
TL;DR: This study demonstrated the unique advantages of melt extrusion over spray drying for the preparation of amorphous solid dispersions of naproxen at high drug level.
References
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Journal ArticleDOI
Pharmaceutical Applications of Solid Dispersion Systems
Win Loung Chiou,Sidney Riegelman +1 more
Book
Polymer Science and Technology
TL;DR: The authors provided the basic building blocks of polymer science and engineering by coverage of fundamental polymer chemistry and materials topics given in Chapters 1 through 7 and provided information on the exciting new materialsnow available and the emerging areas of technological growth that could motivate a new generation of scientists and engineers.
Journal ArticleDOI
Spectroscopic characterization of interactions between PVP and indomethacin in amorphous molecular dispersions.
Lynne S. Taylor,George Zografi +1 more
TL;DR: A comparison of the carbonyl stretching region of γ indomethacin, known to form carboxylic acid dimers, with that of amorphous indometHacin indicated that the amorphously phase exists predominantly as dimers.
Book
Principles of polymer engineering
TL;DR: In this article, the elastic properties of polymeric solids and their properties of rubber are discussed. But they focus on the structure of the molecule rather than the properties of the solids.
Journal ArticleDOI
Melt extrusion: from process to drug delivery technology
TL;DR: Improved bioavailability was achieved again demonstrating the value of the technology as a drug delivery tool, with particular advantages over solvent processes like co-precipitation.