Journal ArticleDOI
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Michael M. Crowley,Feng Zhang,Michael A. Repka,Sridhar Thumma,Sampada B. Upadhye,Sunil Kumar Battu,James W. McGinity,Charles R. Martin +7 more
TLDR
The pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology, are reviewed and the physicochemical properties of the resultant dosage forms are described.Abstract:
Interest in hot-melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicochemical properties of the resultant dosage forms are described. Part II of this review will focus on various applications of HME in drug delivery such as granules, pellets, immediate and modified release tablets, transmucosal and transdermal systems, and implants.read more
Citations
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Journal ArticleDOI
Strategies to Address Low Drug Solubility in Discovery and Development
Hywel David Williams,Natalie L. Trevaskis,Susan A. Charman,Ravi Mysore Shanker,William N. Charman,Colin W. Pouton,Christopher J.H. Porter +6 more
TL;DR: The article provides an integrated and contemporary discussion of current approaches to solubility and dissolution enhancement but has been deliberately structured as a series of stand-alone sections to allow also directed access to a specific technology where required.
Journal ArticleDOI
Current trends and future perspectives of solid dispersions containing poorly water-soluble drugs.
TL;DR: Critical aspects and recent advances in formulation, preparation and characterization of solid dispersions as well as in-depth pharmaceutical solutions to overcome some problems and issues that limit the development and marketability of solid dispersion products are reviewed.
Journal ArticleDOI
Effect of geometry on drug release from 3D printed tablets.
Alvaro Goyanes,Pamela Robles Martinez,Asma B. M. Buanz,Abdul Basit,Simon Gaisford,Simon Gaisford +5 more
TL;DR: This work has demonstrated the potential of 3DP to manufacture tablet shapes of different geometries, many of which would be challenging to manufacture by powder compaction.
Journal ArticleDOI
Manufacture and characterization of mucoadhesive buccal films.
TL;DR: This review will consider the literature that describes the manufacture and characterization of mucoadhesive buccal films and hot-melt extrusion has been explored as an alternative manufacturing process and has yielded promising results.
Journal ArticleDOI
3D Printing of Medicines: Engineering Novel Oral Devices with Unique Design and Drug Release Characteristics
Alvaro Goyanes,Alvaro Goyanes,Jie Wang,Asma B. M. Buanz,Ramón Martínez-Pacheco,Richard Telford,Simon Gaisford,Simon Gaisford,Abdul Basit +8 more
TL;DR: The study confirms the potential of 3D printing to fabricate multiple-drug containing devices with specialized design configurations and unique drug release characteristics, which would not otherwise be possible using conventional manufacturing methods.
References
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Journal ArticleDOI
The use of agar as a novel filler for monolithic matrices produced using hot melt extrusion.
John G. Lyons,Declan M. Devine,James E. Kennedy,Luke M. Geever,Patrick O’Sullivan,Clement L. Higginbotham +5 more
TL;DR: The results detailed within this paper indicate that agar is a viable filler for extended release hot melt produced dosage forms.
Journal ArticleDOI
Influence of the process parameters on the characteristics of starch based hot stage extrudates.
Dominiek Henrist,Jean Paul Remon +1 more
TL;DR: It was concluded that the maximum barrel temperature was the most critical parameter of the hot stage extrusion process and could explain the obtained results.
Journal ArticleDOI
Cold extrusion as a continuous single-step granulation and tabletting process.
TL;DR: Cold extrusion could be used as alternative tablet production technique for ingredients with poor compaction properties, as the tablets prepared by extrusion have a much higher porosity compared with conventional tablets, and could also be useful for tablet production of formulations with poor disintegrating properties.
Journal ArticleDOI
Interaction between water and poly(vinylpyrrolidone) containing polyethylene glycol
TL;DR: In this article, the glass transition temperature (Tg), the point on the isotherm corresponding to the weight of sorbed water required to form a complete monolayer on the solid surface (apparent Wm), and the maximal amount of nonfreezing water, which were measured by differential scanning calorimetry and water sorption isotherms.
Journal ArticleDOI
Compression of controlled-release pellets produced by a hot-melt extrusion and spheronization process.
TL;DR: Investigation of the physicomechanical and dissolution properties of tablets containing controlled-release pellets prepared by a hot-melt extrusion and spheronization process found that tablets with prolonged disintegration times exhibited delayed drug release in acidic media.