Journal ArticleDOI
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Michael M. Crowley,Feng Zhang,Michael A. Repka,Sridhar Thumma,Sampada B. Upadhye,Sunil Kumar Battu,James W. McGinity,Charles R. Martin +7 more
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TLDR
The pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology, are reviewed and the physicochemical properties of the resultant dosage forms are described.Abstract:
Interest in hot-melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicochemical properties of the resultant dosage forms are described. Part II of this review will focus on various applications of HME in drug delivery such as granules, pellets, immediate and modified release tablets, transmucosal and transdermal systems, and implants.read more
Citations
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Journal ArticleDOI
Strategies to Address Low Drug Solubility in Discovery and Development
Hywel David Williams,Natalie L. Trevaskis,Susan A. Charman,Ravi Mysore Shanker,William N. Charman,Colin W. Pouton,Christopher J.H. Porter +6 more
TL;DR: The article provides an integrated and contemporary discussion of current approaches to solubility and dissolution enhancement but has been deliberately structured as a series of stand-alone sections to allow also directed access to a specific technology where required.
Journal ArticleDOI
Current trends and future perspectives of solid dispersions containing poorly water-soluble drugs.
TL;DR: Critical aspects and recent advances in formulation, preparation and characterization of solid dispersions as well as in-depth pharmaceutical solutions to overcome some problems and issues that limit the development and marketability of solid dispersion products are reviewed.
Journal ArticleDOI
Effect of geometry on drug release from 3D printed tablets.
Alvaro Goyanes,Pamela Robles Martinez,Asma B. M. Buanz,Abdul Basit,Simon Gaisford,Simon Gaisford +5 more
TL;DR: This work has demonstrated the potential of 3DP to manufacture tablet shapes of different geometries, many of which would be challenging to manufacture by powder compaction.
Journal ArticleDOI
Manufacture and characterization of mucoadhesive buccal films.
TL;DR: This review will consider the literature that describes the manufacture and characterization of mucoadhesive buccal films and hot-melt extrusion has been explored as an alternative manufacturing process and has yielded promising results.
Journal ArticleDOI
3D Printing of Medicines: Engineering Novel Oral Devices with Unique Design and Drug Release Characteristics
Alvaro Goyanes,Alvaro Goyanes,Jie Wang,Asma B. M. Buanz,Ramón Martínez-Pacheco,Richard Telford,Simon Gaisford,Simon Gaisford,Abdul Basit +8 more
TL;DR: The study confirms the potential of 3D printing to fabricate multiple-drug containing devices with specialized design configurations and unique drug release characteristics, which would not otherwise be possible using conventional manufacturing methods.
References
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Journal ArticleDOI
Physical characterization of pharmaceutical solids.
Harry G. Brittain,Susan J. Bogdanowich,David E. Bugay,Joseph Devincentis,Geoffrey Lewen,Ann Newman +5 more
TL;DR: A general review of the methods available for the physical characterization of pharmaceutical solids is presented in this article, which is classified as being on the molecular level, the particulate level, and the bulk level.
Journal Article
On the physical characterization of pharmaceutical solids
TL;DR: Full physical characterization of three modifications of lactose is presented to illustrate the type of information which can be obtained using each of the techniques discussed.
Journal ArticleDOI
High throughput physicochemical profiling for drug discovery
TL;DR: High throughput methods to measure the properties: solubility, permeability, lipophilicity, pKa, stability and integrity are described and compared and the underlying discovery requirements, needs and application strategies are discussed.
Journal ArticleDOI
Characterization of glass solutions of poorly water-soluble drugs produced by melt extrusion with hydrophilic amorphous polymers.
TL;DR: Depending on the temperature used, melt extrusion produced amorphous glass solutions, with markedly improved dissolution rates compared with crystalline drug, and a significant physicochemical interaction between drug and polymer was found for all extrudates.
Journal ArticleDOI
Physicochemical properties and mechanism of drug release from ethyl cellulose matrix tablets prepared by direct compression and hot-melt extrusion.
Michael M. Crowley,Britta Schroeder,Anke Fredersdorf,Sakae Obara,Mark Talarico,Shawn A. Kucera,James W. McGinity +6 more
TL;DR: The Higuchi diffusion model, Percolation Theory and Polymer Free Volume Theory were applied to the dissolution data to explain the release properties of drug from the matrix systems and the release rate was shown to be dependent on the ethyl cellulose particle size, compaction force and extrusion temperature.