Journal ArticleDOI
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Michael M. Crowley,Feng Zhang,Michael A. Repka,Sridhar Thumma,Sampada B. Upadhye,Sunil Kumar Battu,James W. McGinity,Charles R. Martin +7 more
TLDR
The pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology, are reviewed and the physicochemical properties of the resultant dosage forms are described.Abstract:
Interest in hot-melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicochemical properties of the resultant dosage forms are described. Part II of this review will focus on various applications of HME in drug delivery such as granules, pellets, immediate and modified release tablets, transmucosal and transdermal systems, and implants.read more
Citations
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Journal ArticleDOI
Using containerless methods to develop amorphous pharmaceuticals.
J. K. R. Weber,Chris J. Benmore,Kamlesh J. Suthar,Anthony Tamalonis,O. L. G. Alderman,S. Sendelbach,V. Kondev,Jeffery L. Yarger,C. A. Rey,Stephen R. Byrn +9 more
TL;DR: It was shown that containerless processing using acoustic levitation can be used to make phase-pure forms of drugs that are known to be difficult to amorphize, and containerless techniques can beused to efficiently synthesize small quantities of pure amorphous forms that are potentially useful in pre-clinical trials and for use in the optimization of clinical products.
Patent
Stabilized lipid formulation of apoptosis promoter
Nathaniel D. Catron,Michael G. Fickes,Cristina M. Fischer,Anthony R. Haight,Katherine Heemstra,Yeshwant D. Sanzgiri,Eric A. Schmitt,Ping Tong,Geoff G. Z. Zhang,Deliang Zhou +9 more
TL;DR: In this paper, an orally deliverable pharmaceutical composition comprises a Bcl-2 family protein inhibitory compound, e.g., ABT-263, a heavier-chalcogen antioxidant and a substantially non-aqueous lipid carrier, wherein said compound and said antioxidant are in solution in the carrier.
Journal ArticleDOI
Hot-melt extrusion and prilling as contemporary and promising techniques in the solvent free production of solid oral dosage forms, based on solid dispersions
TL;DR: In this article, the authors present a review of hot-melt extrusion and prilling in terms of understanding process basics, equipment characteristics, required properties of processed materials and application of the processes for development of solid oral dosage forms.
Patent
Hypromellose acetate succinate for use as hot-melt extrusion carrier, hot-melt extrusion composition, and method for producing hot-melt extrudate
TL;DR: In this paper, a hot-melt extrusion carrier with a volume average particle size (D) of 70-300 μm and a loose bulk density of 0.25-0.40 g/cm is presented.
Book ChapterDOI
Solid dispersions: technologies used and future outlook
Niten Jadav,Anant Paradkar +1 more
TL;DR: One of the major challenges in pharmaceutical drug discovery and development is to find out different novel ways to enhance the solubility and dissolution rate of these drugs.
References
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Journal ArticleDOI
Pharmaceutical Applications of Solid Dispersion Systems
Win Loung Chiou,Sidney Riegelman +1 more
Book
Polymer Science and Technology
TL;DR: The authors provided the basic building blocks of polymer science and engineering by coverage of fundamental polymer chemistry and materials topics given in Chapters 1 through 7 and provided information on the exciting new materialsnow available and the emerging areas of technological growth that could motivate a new generation of scientists and engineers.
Journal ArticleDOI
Spectroscopic characterization of interactions between PVP and indomethacin in amorphous molecular dispersions.
Lynne S. Taylor,George Zografi +1 more
TL;DR: A comparison of the carbonyl stretching region of γ indomethacin, known to form carboxylic acid dimers, with that of amorphous indometHacin indicated that the amorphously phase exists predominantly as dimers.
Book
Principles of polymer engineering
TL;DR: In this article, the elastic properties of polymeric solids and their properties of rubber are discussed. But they focus on the structure of the molecule rather than the properties of the solids.
Journal ArticleDOI
Melt extrusion: from process to drug delivery technology
TL;DR: Improved bioavailability was achieved again demonstrating the value of the technology as a drug delivery tool, with particular advantages over solvent processes like co-precipitation.