Journal ArticleDOI
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Michael M. Crowley,Feng Zhang,Michael A. Repka,Sridhar Thumma,Sampada B. Upadhye,Sunil Kumar Battu,James W. McGinity,Charles R. Martin +7 more
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TLDR
The pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology, are reviewed and the physicochemical properties of the resultant dosage forms are described.Abstract:
Interest in hot-melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicochemical properties of the resultant dosage forms are described. Part II of this review will focus on various applications of HME in drug delivery such as granules, pellets, immediate and modified release tablets, transmucosal and transdermal systems, and implants.read more
Citations
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Journal ArticleDOI
Dry Powder Mixing Is Feasible in Continuous Twin Screw Extruder: Towards Lean Extrusion Process for Oral Solid Dosage Manufacturing.
Daniel Mateo-Ortiz,Vladimir Villanueva-López,Shashank Venkat Muddu,Gregory D. Doddridge,Dana Alhasson,Michael C. Dennis +5 more
TL;DR: In this article, the feasibility of powder mixing in the initial pre-melting zones of a twin screw extruder using two independent feeders was studied using discrete element method (DEM) modeling and near-infrared (NIR) spectroscopy.
Extrudierte feste Dispersionen zur Verbesserung der Lösungsgeschwindigkeit und Bioverfügbarkeit
TL;DR: In this paper, a model for untersuchung der Verweilzeitverteilung bei einer Extrusion fester Dispersionen wurde entwickelt.
Journal ArticleDOI
Development of binary dispersions and nanocomposites of irbesartan with enhanced antihypertensive activity.
TL;DR: In vivo studies indicated that the induction of systolic and diastolic blood pressure in the optimized formulation (NC1) was significantly decreased in comparison to the disease control group at all time intervals along with pure drug.
Journal ArticleDOI
Investigating the effects of material properties on the mixing dynamics of cohesive particles in a twin screw mixer using a discrete element method approach
TL;DR: In this paper , a discrete element method (DEM) model was developed for a co-rotating twin-screw mixer (TSM) consisting of conveying and kneading elements.
Dissertation
Raman chemical and physical mapping of oral dosage forms
TL;DR: In this paper, the dissolution performance of three solid dispersions model systems including felodipine, bicalutamide and indomethacin, all poorly soluble drugs, with copovidone, a water-soluble polymer.
References
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Journal ArticleDOI
Pharmaceutical Applications of Solid Dispersion Systems
Win Loung Chiou,Sidney Riegelman +1 more
Book
Polymer Science and Technology
TL;DR: The authors provided the basic building blocks of polymer science and engineering by coverage of fundamental polymer chemistry and materials topics given in Chapters 1 through 7 and provided information on the exciting new materialsnow available and the emerging areas of technological growth that could motivate a new generation of scientists and engineers.
Journal ArticleDOI
Spectroscopic characterization of interactions between PVP and indomethacin in amorphous molecular dispersions.
Lynne S. Taylor,George Zografi +1 more
TL;DR: A comparison of the carbonyl stretching region of γ indomethacin, known to form carboxylic acid dimers, with that of amorphous indometHacin indicated that the amorphously phase exists predominantly as dimers.
Book
Principles of polymer engineering
TL;DR: In this article, the elastic properties of polymeric solids and their properties of rubber are discussed. But they focus on the structure of the molecule rather than the properties of the solids.
Journal ArticleDOI
Melt extrusion: from process to drug delivery technology
TL;DR: Improved bioavailability was achieved again demonstrating the value of the technology as a drug delivery tool, with particular advantages over solvent processes like co-precipitation.