Journal ArticleDOI
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Michael M. Crowley,Feng Zhang,Michael A. Repka,Sridhar Thumma,Sampada B. Upadhye,Sunil Kumar Battu,James W. McGinity,Charles R. Martin +7 more
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TLDR
The pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology, are reviewed and the physicochemical properties of the resultant dosage forms are described.Abstract:
Interest in hot-melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicochemical properties of the resultant dosage forms are described. Part II of this review will focus on various applications of HME in drug delivery such as granules, pellets, immediate and modified release tablets, transmucosal and transdermal systems, and implants.read more
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Journal ArticleDOI
Potential of solid dispersions to enhance solubility, bioavailability, and therapeutic efficacy of poorly water-soluble drugs: newer formulation techniques, current marketed scenario and patents.
Sultan Alshehri,Syed Sarim Imam,Afzal Hussain,Mohammad A. Altamimi,Nabil K. Alruwaili,Fahad Alotaibi,Abdullah G. Alanazi,Faiyaz Shakeel +7 more
TL;DR: Current literature of novel methodologies for SD preparation to enhance the dissolution rate, solubility, therapeutic efficacy, and bioavailability of poorly water-soluble drugs has been summarized and analyzed.
Journal ArticleDOI
Compositional Analysis of Low Quantities of Phase Separation in Hot-Melt-Extruded Solid Dispersions: A Combined Atomic Force Microscopy, Photothermal Fourier-Transform Infrared Microspectroscopy, and Localised Thermal Analysis Approach
TL;DR: It is demonstrated that the novel combined approach allows site-specific characterisation of the extruded systems and that drug distribution may be uneven across the extrudates, with concomitant implications for understanding stability and drug release behaviour.
Journal ArticleDOI
Customized Novel Design of 3D Printed Pregabalin Tablets for Intra-Gastric Floating and Controlled Release Using Fused Deposition Modeling
TL;DR: The results show that FDM printing is suitable for the formulation of floating dosage form with the desired drug release profile and that drug release is faster in an open system with low infill percentage compared to closed systems and open systems with a high infill ratio.
Journal ArticleDOI
Klucel™ EF and ELF polymers for immediate-release oral dosage forms prepared by melt extrusion technology
Noorullah Naqvi Mohammed,Soumyajit Majumdar,Abhilasha Singh,Weibin Deng,Narasimha Murthy,Elanor Pinto,Divya Tewari,Thomas Durig,Michael A. Repka +8 more
TL;DR: The release obtained from pellets was carrier-dependent and not drug-dependent, and hence, such a system can be effectively utilized to address solubility or precipitation issues with poorly soluble drugs in the gastrointestinal environment.
Journal ArticleDOI
3D Printing of Metformin HCl PVA Tablets by Fused Deposition Modeling: Drug Loading, Tablet Design, and Dissolution Studies
Mariam Ibrahim,Morgan Barnes,Robert McMillin,Daniel Cook,Sarah E. Smith,Mathew Halquist,Dayanjan S. Wijesinghe,Thomas D. Roper +7 more
TL;DR: The results show a simple approach to increase metformin HCl loading onto PVA and reveal the significance of tablet design, infill percentage, and printing pattern as they dictate the area, volume, and the mass of the tablet which impact its dissolution rate.
References
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Journal ArticleDOI
Pharmaceutical Applications of Solid Dispersion Systems
Win Loung Chiou,Sidney Riegelman +1 more
Book
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TL;DR: The authors provided the basic building blocks of polymer science and engineering by coverage of fundamental polymer chemistry and materials topics given in Chapters 1 through 7 and provided information on the exciting new materialsnow available and the emerging areas of technological growth that could motivate a new generation of scientists and engineers.
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Spectroscopic characterization of interactions between PVP and indomethacin in amorphous molecular dispersions.
Lynne S. Taylor,George Zografi +1 more
TL;DR: A comparison of the carbonyl stretching region of γ indomethacin, known to form carboxylic acid dimers, with that of amorphous indometHacin indicated that the amorphously phase exists predominantly as dimers.
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TL;DR: In this article, the elastic properties of polymeric solids and their properties of rubber are discussed. But they focus on the structure of the molecule rather than the properties of the solids.
Journal ArticleDOI
Melt extrusion: from process to drug delivery technology
TL;DR: Improved bioavailability was achieved again demonstrating the value of the technology as a drug delivery tool, with particular advantages over solvent processes like co-precipitation.