Journal ArticleDOI
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Michael M. Crowley,Feng Zhang,Michael A. Repka,Sridhar Thumma,Sampada B. Upadhye,Sunil Kumar Battu,James W. McGinity,Charles R. Martin +7 more
TLDR
The pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology, are reviewed and the physicochemical properties of the resultant dosage forms are described.Abstract:
Interest in hot-melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicochemical properties of the resultant dosage forms are described. Part II of this review will focus on various applications of HME in drug delivery such as granules, pellets, immediate and modified release tablets, transmucosal and transdermal systems, and implants.read more
Citations
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Journal ArticleDOI
Molecular Indicators of Surface and Bulk Instability of Hot Melt Extruded Amorphous Solid Dispersions
TL;DR: The stability of the amorphous drug-rich domains appears to be governed by the physical stabilities of theAmorphous drugs, with a higher degree of instability at the surface of the material in comparison to the bulk.
Journal ArticleDOI
A solution for low-dose feeding in continuous pharmaceutical processes.
TL;DR: A novel micro-feeder system was integrated into a continuous manufacturing line and its capability to supply API at feed rates down to one gram per hour was tested, indicating its high potential for continuous process implementation.
Journal ArticleDOI
A Comparison Between Lab-Scale and Hot-Melt-Extruder-Based Anti-inflammatory Ointment Manufacturing
Rishi Thakkar,Eman A. Ashour,Ashay Shukla,Rui Wang,Walter G. Chambliss,Suresh Bandari,Narasimha Murthy,Michael A. Repka +7 more
TL;DR: This study aimed to explore the applicability of HME in the continuous manufacturing of topical semi-solid formulations with two active pharmaceutical ingredients (APIs) and demonstrated its applicability in the manufacturing of semisolids.
Journal ArticleDOI
Fabrication of bilayer tablets using hot melt extrusion-based dual-nozzle fused deposition modeling 3D printing.
TL;DR: In this article , the authors used hot-melt extrusion (HME)-based dual-nozzle fused deposition modeling (FDM) 3D printing techniques to fabricate bilayer tablets.
Journal ArticleDOI
Investigating a Novel Hot Melt Extrusion-Based Drying Technique to Solidify an Amorphous Nanosuspension Using Design of Experiment Methodology
TL;DR: A well-designed study implemented by DoE aided in developing a robust and novel HME technique to dry aqueous nanosuspension, and reveals feed rate and input temperature as significant independent variables, critically influencing RDI and moisture content of solidified end product.
References
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Journal ArticleDOI
Pharmaceutical Applications of Solid Dispersion Systems
Win Loung Chiou,Sidney Riegelman +1 more
Book
Polymer Science and Technology
TL;DR: The authors provided the basic building blocks of polymer science and engineering by coverage of fundamental polymer chemistry and materials topics given in Chapters 1 through 7 and provided information on the exciting new materialsnow available and the emerging areas of technological growth that could motivate a new generation of scientists and engineers.
Journal ArticleDOI
Spectroscopic characterization of interactions between PVP and indomethacin in amorphous molecular dispersions.
Lynne S. Taylor,George Zografi +1 more
TL;DR: A comparison of the carbonyl stretching region of γ indomethacin, known to form carboxylic acid dimers, with that of amorphous indometHacin indicated that the amorphously phase exists predominantly as dimers.
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Principles of polymer engineering
TL;DR: In this article, the elastic properties of polymeric solids and their properties of rubber are discussed. But they focus on the structure of the molecule rather than the properties of the solids.
Journal ArticleDOI
Melt extrusion: from process to drug delivery technology
TL;DR: Improved bioavailability was achieved again demonstrating the value of the technology as a drug delivery tool, with particular advantages over solvent processes like co-precipitation.