Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
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The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
Citations
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Low molecular weight heparin for prevention of thromboembolic complications in cardioversion--rationale and design of the ACE study (Anticoagulation in Cardioversion using Enoxaparin).
Christoph Stellbrink,Peter Hanrath,Uwe Nixdorff,T. Hofmann,Walter Lehmacher,K. Kühle,Thomas Fetsch,R. Grewe,J.-A. Schmidt-Lucke +8 more
TL;DR: Low-molecular weight heparin is an attractive alternative as it not only provides a safe and predictable level of anticoagulation with fewer side effects but can also be administered safely on an outpatient basis.
Journal ArticleDOI
Tratamiento médico de la insuficiencia cardíaca basado en la evidencia
Antònia Agustí Escasany,Marta Durán Dalmau,Dolores Rodríguez Cumplido,Eduard Diogène Fadini,Josep M. Arnau de Bolós,José Casas Rodríguez,Enrique Galve Basilio,Nicolás Manito Lorite +7 more
TL;DR: Las pautas de tratamiento han sido definidas en funcion of la clase funcional de the NYHA y se han clasificado en las categorias A, B o C segun el nivel de calidad of the evidencia disponible.
Journal ArticleDOI
Current Guidelines for the Treatment of Congestive Heart Failure
Franz X. Kleber,Roland Wensel +1 more
TL;DR: The role of the currently used drugs in the treatment of CHF is appraised, considering effects on pathophysiology and clinical outcome and an approach to a differential drug regimen is provided.
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How to invest in getting cost-effective technologies into practice? : A framework for value of implementation analysis applied to novel oral anticoagulants
TL;DR: A framework is proposed to use cost-effectiveness analysis to inform decisions on how best to invest in implementation activities and suggests that there is value in additional implementation activities to improve uptake of NOACs, particularly in targeting patients with average or poor warfarin control.
Journal ArticleDOI
Sinus node disease. Current concepts in diagnosis and therapy.
J F Sneddon,A J Camm +1 more
TL;DR: Treatment of bradyarrhythmias should be permanent pacing, and long term oral anticoagulation should be considered to reduce the risk of systemic embolisation which is a common complication in patients with the bradycardia/tachycardia syndrome.
References
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Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
Journal ArticleDOI
Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
Journal ArticleDOI
Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
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