Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
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TLDR
The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
Citations
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Journal ArticleDOI
Atrial fibrillation: Current understandings and research imperatives
TL;DR: The epidemiology of atrial fibrillation is discussed and of the etiology, mechanism, management and future research directions in the study of this arrhythmia are discussed.
Journal ArticleDOI
Ventricular thrombi and thromboembolism in dilated cardiomyopathy: A prospective follow-up study
TL;DR: It is concluded that in nonanticoagulated patients with dilated cardiomyopathy left ventricular thrombus and thromboembolism are common, and echocardiography may be helpful in predicting which patients are at risk of thrombosis.
Journal ArticleDOI
Worldwide management of oral anticoagulant therapy: the ISAM study.
TL;DR: Studying of anticoagulation management based on local models of care highlights important discrepancies among countries and suggests further standardization of the management of this important therapy is necessary.
Journal ArticleDOI
New-onset atrial fibrillation and warfarin initiation: High risk periods and implications for new antithrombotic drugs
TL;DR: In this paper, a review suggests that the risk of both haemorrhage and stroke are highest when atrial fibrillation is newly diagnosed and during the initiation of anticoagulant medication.
Journal ArticleDOI
Risk factors for stroke in patients with nonrheumatic atrial fibrillation: a case-control study.
Anne W. Moulton,Anne W. Moulton,Anne W. Moulton,Daniel E. Singer,Daniel E. Singer,Daniel E. Singer,Jennifer S. Haas,Jennifer S. Haas,Jennifer S. Haas +8 more
TL;DR: Age and hypertension should be considered when deciding upon long-term anticoagulant therapy to prevent stroke in patients with nonrheumatic atrial fibrillation, using case-control methodology.
References
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Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
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Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
Journal ArticleDOI
Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
Related Papers (5)
Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke
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