Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
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TLDR
The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
Citations
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Journal ArticleDOI
Lewis A. Conner Lecture. Contributions of epidemiology to the prevention of stroke.
TL;DR: The remarkable decline in stroke mortality clearly shows that stroke is preventable and not an inevitable consequence of aging but rather a chain of events set in motion many years before.
Journal ArticleDOI
Discontinuation/Interruption of Warfarin Therapy in Patients with Nonvalvular Atrial Fibrillation.
Christina A. Spivey,Yanru Qiao,Xianchen Liu,Xianchen Liu,Jack Mardekian,Robert B. Parker,Hemant Phatak,A.B. Claflin,Sumesh Kachroo,Younos Abdulsattar,Anwesa Chakrabarti,Junling Wang +11 more
TL;DR: A retrospective cohort study on the rates and predictors of warfarin discontinuation/interruption in patients with nonvalvular AF in the usual clinical practice settings in the United States to determine demographic, clinical, and health care-related factors associated with discontinuation and interruption.
Journal ArticleDOI
Cost-effectiveness of a community-based screening programme for chronic atrial fibrillation in Japan.
Kenji Maeda,T Shimbo,T Fukui +2 more
TL;DR: To prevent ischaemic stroke associated with AF, both annual ECG screening and annual palpation screening were favourable in the context of conventional criteria for cost-effectiveness.
Journal ArticleDOI
Comparative effects of antiplatelet, anticoagulant, or combined therapy in patients with valvular and nonvalvular atrial fibrillation
Francisco Pérez-Gómez,Eduardo Alegría,Jesus Berjón,Jose A. Iriarte,Javier Zumalde,Antonio Salvador,Luis Mataix,Naspeaf Investigators +7 more
TL;DR: The combined antiplatelet plus moderate-intensity anticoagulation therapy significantly decreased the vascular events compared with anticoAGulation alone and proved to be safe in atrial fibrillation patients.
Journal ArticleDOI
Bridging of Chronic Oral Anticoagulation with Enoxaparin in Patients with Atrial Fibrillation: Results from the Prospective BRAVE Registry
TL;DR: The study supports a predefined bridging regimen based on the individual patient's TE risk and renal function, and shows patients with low TE risk or with impaired renal function can be bridged effectively and safely with reduced LMWH doses.
References
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Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
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Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
Journal ArticleDOI
Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
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