Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
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TLDR
The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
Citations
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Journal ArticleDOI
Predictors of systemic embolism in patients with mitral stenosis. A prospective study
TL;DR: Systemic, especially cerebral, embolism is one of the major causes of illness and death in patients with mitral stenosis and this issue was sought to reappraise this issue in a large, prospective study.
Journal ArticleDOI
Treatment of atrial fibrillation in a district general hospital.
TL;DR: Standard investigations were inadequately used in patients with atrial fibrillation and there was a reluctance to perform cardioversion or to start anticoagulant treatment.
Journal ArticleDOI
Why isn’t warfarin prescribed to patients with nonrheumatic atrial fibrillation?
Rebecca J. Beyth,Meghal R. Antani,Kenneth E. Covinsky,David G. Miller,Mary-Margaret Chren,Linda M. Quinn,C. Seth Landefeld +6 more
TL;DR: Physicians’ opinions frequently opposed warfarin for older patients with nonrheumatic atrial fibrillation, and for those with bleeding risk factors, most likely contribute to its infrequent prescription.
Journal ArticleDOI
Higher Persistence in Newly Diagnosed Nonvalvular Atrial Fibrillation Patients Treated With Dabigatran Versus Warfarin
Martin Zalesak,Kimberly Siu,Kevin P. Francis,Chen Yu,Hasmik Alvrtsyan,Yajing Rao,David R Walker,Stephen Sander,Gavin Miyasato,David B. Matchar,Herman Sanchez +10 more
TL;DR: Patients who initiated dabigatran treatment were more persistent than patients who began warfarin treatment, and patients with lower stroke risk were more likely to discontinue therapy.
Journal ArticleDOI
Improvements in 1-Year Cardiovascular Clinical Outcomes Associated with a Hospital-Based Discharge Medication Program
Jason M. Lappe,Joseph B. Muhlestein,Donald L. Lappé,Rodney S. Badger,Tami L Bair,Ruth Brockman,Thomas K. French,Linda C. Hofmann,Benjamin D. Horne,Susan Kralick-Goldberg,Nan Nicponski,Janette A. Orton,Robert R. Pearson,Dale G. Renlund,Holly L. Rimmasch,Colleen Roberts,Jeffrey L. Anderson +16 more
TL;DR: The feasibility of implementing a comprehensive quality improvement initiative in a large multihospital network to significantly increase rates of prescription at discharge of evidence-based, secondary prevention medications for life-threatening cardiovascular diseases was determined.
References
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Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
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Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
Journal ArticleDOI
Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
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Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke
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