Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
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TLDR
The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
Citations
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Journal ArticleDOI
Use of Ordinal Outcomes in Vascular Prevention Trials Comparison With Binary Outcomes in Published Trials
TL;DR: In this article, the authors used ordinal outcomes to compare two ordinal or binary treatment groups and found that the ordinal outcome test was more efficient than the binary test for stroke events.
Journal ArticleDOI
Retrospective investigation of hospitalised patients with atrial fibrillation in mainland China.
TL;DR: Most of the atrial fibrillation-related epidemiological factors in this population were similar to those reported in other countries.
Journal ArticleDOI
Asymptomatic coronary artery disease in patients with stroke. Prevalence, prognosis, diagnosis, and treatment.
Marc I. Chimowitz,G B Mancini +1 more
TL;DR: Preliminary data from nonrandomized studies suggest that coronary artery bypass surgery significantly lowers cardiac mortality in patients with asymptomatic 3-vessel or left main CAD.
Journal ArticleDOI
Clinical and Safety Outcomes of Oral Antithrombotics for Stroke Prevention in Atrial Fibrillation: A Systematic Review and Network Meta-analysis
Liang Lin,Wee Shiong Lim,Hui Jun Zhou,Ai Leng Khoo,Keng Teng Tan,Aik Phon Chew,David Foo,Jing Jih Chin,Boon Peng Lim +8 more
TL;DR: Clinical and safety outcomes of oral antithrombotics for stroke prevention in AF in younger (65-74 years) and older (≥75 years) elderly are compared and lower rates of SSE and intracranial bleeding were observed with the NOACs compared with warfarin.
Journal ArticleDOI
Systematic review and network meta-analysis of stroke prevention treatments in patients with atrial fibrillation.
Amy Tawfik,Joanna M. Bielecki,Murray Krahn,Paul Dorian,Jeffrey S Hoch,Heather Boon,Don Husereau,Petros Pechlivanoglou +7 more
TL;DR: All oral anticoagulants were more effective than antiplatelet agents at reducing the risk of ischemic stroke and all strokes and individual treatment recommendations should also consider the patient’s underlying stroke and bleeding risk profile.
References
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Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
Journal ArticleDOI
Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
Journal ArticleDOI
Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
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