Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
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TLDR
The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
Citations
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Journal ArticleDOI
Oral Anticoagulation and Hemorrhagic Complications in an Elderly Population With Atrial Fibrillation
TL;DR: Findings suggest that the elderly population attending the anticoagulant clinic did not have poorer anticoageulant control or an increased incidence of hemorrhage while receiving warfarin therapy.
Journal ArticleDOI
Newly Diagnosed Atrial Fibrillation
TL;DR: A 77-year-old woman with a history of hypertension treated with metoprolol presents for her annual examination, and Electrocardiographic testing reveals atrial fibrillation at an average rate of 75 beats per minute.
Journal ArticleDOI
Surgical management of severe acute lower extremity ischemia.
Richard A. Yeager,Gregory L. Moneta,Lloyd M. Taylor,Daniel W. Hamre,Donald B. McConnell,John M. Porter +5 more
TL;DR: It is concluded that management of severe, acute lower limb ischemia with early amputation of nonviable limbs and heparinization, angiography, and prompt operative revascularization for threatened but viable extremities minimizes morbidity and mortality rates, while maximizing limb salvage.
Journal ArticleDOI
Thromboembolism Prophylaxis in Chronic Atrial Fibrillation Practice Patterns in Community and Tertiary-Care Hospitals
TL;DR: Thromboembolism prophylaxis with either AC or AP agents is underutilized in the setting of atrial fibrillation and the use of clinical guidelines suggested by trials of thrombo embolization in AF could reduce the incidence of stroke.
Journal ArticleDOI
Betrixaban compared with warfarin in patients with atrial fibrillation: results of a phase 2, randomized, dose-ranging study (Explore-Xa).
Stuart J. Connolly,John W. Eikelboom,Paul Dorian,Stefan H. Hohnloser,Daniel D. Gretler,Uma Sinha,Michael D. Ezekowitz +6 more
TL;DR: Betrixaban was well tolerated and had similar or lower rates of bleeding compared with well-controlled warfarin in patients with AF at risk for stroke.
References
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Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
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Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
Journal ArticleDOI
Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
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