Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
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TLDR
The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
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Long term aspirin in the prevention of cardiovascular disorders : recent developments and variations on a theme
TL;DR: Results achieved with the intravenously administered monoclonal antibody abciximab, have demonstrated that the efficacy of IIb/IIIa antagonists is additive to that of aspirin, which should be considered to have established efficacy as treatment for the long term prevention of cardiovascular events.
Journal ArticleDOI
Pharmacologic management of atrial fibrillation.
TL;DR: This review will address pharmacologic approaches designed to: slow ventricular response; restore sinus rhythm; reduce occurrences of atrial fibrillation; and prevent thromboembolic complications.
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Physicians' attitudes and the use of oral anticoagulants: surveying the present and envisioning future.
TL;DR: Better adherence to evidence-driven guidelines, better patient and physician education, point-of-care monitoring of INR and the future development of user friendly anticoagulant drugs are likely to result in higher rates of antICOagulation use.
Journal ArticleDOI
Factors relevant to preventing embolic stroke in patients with non-rheumatic atrial fibrillation
TL;DR: This method of analysis suggests that for most patients anticoagulants are beneficial and that the most important factor in determining this result is the value that subjects put on different outcomes.
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Cardiogenic embolism in the cat.
TL;DR: This review will attempt to present a summary of where the authors stand in 2015 with regards to clinical presentation, survival, thrombotic risk, and prevention in cats.
References
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Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
Journal ArticleDOI
Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
Journal ArticleDOI
Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
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Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke
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