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Journal ArticleDOI

Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.

Palle Petersen, +4 more
- 28 Jan 1989 - 
- Vol. 333, Iss: 8631, pp 175-179
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TLDR
The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.
About
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.

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Citations
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Risk factors and determinants in the Copenhagen Stroke Study

TL;DR: This thesis focuses on the survival after stroke in relation to several baseline clinical characteristics and risk factors for cardiovascular disease, which comprises a cohort of 1197 patients with acute stroke admitted to a single stroke unit and recruited from a well-defined area in Copenhagen, Denmark.
Journal ArticleDOI

Management of Arrhythmias in the Emergency Department

TL;DR: The authors present practical and concise advice on initial diagnosis and management of arrhythmias, on arrhythmia devices, and on syncope.
Journal ArticleDOI

Atrial fibrillation and anticoagulation in a stroke unit population

TL;DR: A prevalence of AF in an Australian stroke unit is assessed to determine the degree of undertreatment at presentation and there is evidence to suggest that even in appropriate candidates warfarin therapy is underutilized.
Journal ArticleDOI

Frequency of magnetic resonance signal abnormalities of the brain in patients aged <50 years with idiopathic dilated cardiomyopathy

TL;DR: The data indicate a high incidence of parenchymal abnormalities of the brain in young, neurologically asymptomatic patients with idiopathic dilated cardiomyopathy, and the duration of clinical evidence of IDC.
Journal ArticleDOI

Adecuación de la profilaxis tromboembólica en pacientes con fibrilación auricular crónica en 3 centros de atención primaria

TL;DR: Un alto porcentaje de pacientes con fibrilacion auricular cronica y alto riesgo of embolia that no reciben una adecuada PTE, en ausencia of contraindicaciones para the anticoagulacion oral.
References
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Journal ArticleDOI

A multiple testing procedure for clinical trials.

TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
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Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study

TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
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Explanatory and pragmatic attitudes in therapeutical trials

TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
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Randomised trial of prophylactic daily aspirin in British male doctors

TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI

The natural history of lone atrial fibrillation. A population-based study over three decades.

TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
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