Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
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TLDR
The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
Citations
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Journal ArticleDOI
Management and comorbidities of atrial fibrillation in patients admitted in cardiology service in Kosovo-a single-center study.
TL;DR: The independent predictors of under prescription of anticoagulants in patients with atrial fibrillation were elder age, non-enlarged left atrium, and good left ventricular ejection fraction.
Journal ArticleDOI
Atrial fibrillation and its relationship to dental care.
TL;DR: It is found that complications can arise from AF and that medical management of AF can affect the delivery of dental care, and appropriate guidelines for dental treatment of patients with AF are found.
Journal ArticleDOI
Effect of warfarin versus aspirin on blood viscosity in cardioembolic stroke with atrial fibrillation: a prospective clinical trial
TL;DR: Warfarin confers greater reductions in BV than aspirin in patients with acute cardioembolic stroke and could be a useful method to estimate thrombotic risk in patients receiving warfarin.
Ablation Procedures for Rhythm Control in Patients with Atrial Fibrillation: Clinical and Cost-Effectiveness Analyses
Nazila Assasi,Gord Blackhouse,Feng Xie,K Gaebel,D Robertson,Robert Hopkins,Jeff S. Healey,Denis C. Roy,Ron Goeree +8 more
TL;DR: The objectives of this report were to compare the clinical and cost-effectiveness of minimally invasive ablation procedures for AF with those of other modalities for converting AF to normal sinus rhythm (NSR), and to evaluate the health services impact of funding AF ablation Procedures.
Journal ArticleDOI
Which parameters differ in very old patients with chronic atrial fibrillation treated by anticoagulant or aspirin
Jean Doucet,Emmanuelle Gréboval-Furstenfeld,Alain Tavildari,Luc M’bello,Olympe Delaunay,Thierry Pesqué,P. Moirot,Dominique Mouton-Schleifer +7 more
TL;DR: The two groups did not significantly differ for death, bleeding or ischaemic events, and in common practice, the decision of antithrombotic treatment for AF should take into account not only cardiovascular but also geriatric criteria.
References
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Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
Journal ArticleDOI
Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
Journal ArticleDOI
Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
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