Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
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The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
Citations
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Journal ArticleDOI
Short Deceleration Time of Mitral Inflow E Velocity: Prognostic Implication with Atrial Fibrillation Versus Sinus Rhythm☆☆☆★
TL;DR: Restrictive physiology as defined by Doppler echocardiography (deceleration time < or = 130 msec) appears to predict a similar poor prognosis with AF as with SR.
Journal ArticleDOI
Clinical trials update from the American Heart Association meeting: Omega-3 fatty acids and arrhythmia risk in patients with an implantable defibrillator, ACTIV in CHF, VALIANT, the Hanover autologous bone marrow transplantation study, SPORTIF V, ORBIT and PAD and DEFINITE.
John G.F. Cleland,Nick Freemantle,Gerry Kaye,Mansoor Nasir,Periaswamy Velavan,Krishna Lalukota,Telal Mudawi,Rhidian J. Shelton,Andrew L. Clark,Alison P. Coletta +9 more
TL;DR: The American Heart Association meeting reported the results of several clinical trials of particular interest to those who care for patients with heart failure, including a role for ICDs in patients with non‐ischemic cardiomyopathy, although cost‐effectiveness remains in doubt.
Journal ArticleDOI
Low-dose amiodarone for atrial fibrillation: time for a prospective study?
TL;DR: The time has come for a large-scale prospective evaluation of low-dose amiodarone treatment early in the course of atrial fibrillation, which has a lower incidence of proarrhythmia and heart failure exacerbation compared with class I drugs and is well tolerated.
Journal ArticleDOI
Innovations in framework synthesis as a systematic review method
TL;DR: A spectrum of approaches to framework synthesis that are dependent on the extent to which theory is tentative, emergent, refined, or established are demonstrated; and that stakeholder involvement may help to understand the topic's complexity where theory is more nascent.
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Increase and redistribution of cardiac mast cells in auricular thrombosis. Possible role of kit ligand.
Hans Bankl,T. Radaszkiewicz,Günter Klappacher,Dietmar Glogar,Wolfgang R. Sperr,Karl Grossschmidt,Hans Christian Bankl,Klaus Lechner,Peter Valent +8 more
TL;DR: Evidence is provided that AUTHR is associated with MC increase and redistribution and MGF overexpression and the role of redistributed MC and their mediators in the pathophysiology of atrial thrombosis requires further investigation.
References
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Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
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Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
Journal ArticleDOI
Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
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