Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
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TLDR
The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
Citations
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Journal ArticleDOI
Trends in case-fatality in 22 968 patients admitted for the first time with atrial fibrillation in Scotland, 1986–1995
Simon Stewart,Kate MacIntyre,James W. T. Chalmers,James Boyd,Alan Finlayson,Adam Redpath,Jill P. Pell,Simon Capewell,Jjv McMurray +8 more
TL;DR: The number of first-ever hospitalisations for AF has increased twofold during the 10-year period 1986-1995 and the age of patients has progressively increased during this period, short and medium case-fatality rates have declined, especially in men.
Journal ArticleDOI
Atrial fibrillation: prevalence and management in an acute general medical unit.
TL;DR: This patient group had a high risk for thromboembolism and after excluding the large group in whom warfarin was contraindicated, warfar in was still under-utilised.
Journal ArticleDOI
Use of Oral Anticoagulants in Older Patients
TL;DR: Older patients with either paroxysmal or persistent NVAF and most other cardiovascular conditions increases with advancing age, many elderly patients will be candidates for thromboprophylaxis and the potential benefit of long term anticoagulation must be carefully weighed against the risk of serious haemorrhage in such patients.
Journal ArticleDOI
Underuse of oral anticoagulants in patients with nonvalvular atrial fibrillation in Italy
TL;DR: Underuse of OAs is still common in Italy, and much of it cannot be explained by the concern for haemorrhage, so support and training in the complex task of anticoagulation management may help to extend this efficacious prophylactic therapy to all patients who may benefit from it.
Journal ArticleDOI
Effect of On-Admission Antiplatelet Treatment on Patients with Cerebral Hemorrhage
Valeria Caso,Maurizio Paciaroni,Michele Venti,Andrea Alberti,Francesco Palmerini,Paolo Milia,Antonia M.R. Billeci,Giorgio Silvestrelli,Sergio Biagini,Giancarlo Agnelli +9 more
TL;DR: Hemorrhagic stroke continues to be responsible for a high percentage of disability and death, and it was seen here that functional outcome was independent of previous antiplatelet treatment.
References
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Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
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Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
Journal ArticleDOI
Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
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