Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
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TLDR
The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
Citations
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Journal ArticleDOI
Heart–brain relationship: atrial fibrillation and stroke
TL;DR: In this article, randomized trials have shown that anticoagulation and aspirin are safe in patients with NVAF, leading to 70% and 22% risk reduction of strokes, respectively.
Journal ArticleDOI
Neurologia y cardiologia: puntos de contacto
TL;DR: Cardiologists and neurologists share responsibility for caring for patients with or at risk for cardiogenic strokes, and for screening and managing the heart disease associated with neuromuscular disorders.
Journal ArticleDOI
Propafenone and sotalol in the prevention of paroysmal atrial fibrillation: long-term safety and efficacy study
TL;DR: The efficacy and tolerability of propafenone and sotalol in the prevention of paroysmal atrial fibrillation (AF) were assessed in a doubleblind placebo-controlled study over 1 year.
Journal ArticleDOI
Does warfarin enhance platelet activity
C Mieszczak,K Winther +1 more
TL;DR: The aim of the present study was to test if warfarin affects platelet aggregation induced by ADP, adrenaline and collagen, and to determine if the enhancement of platelet activation is indeed caused by Warfarin.
Journal ArticleDOI
Should all patients with atrial fibrillation be screened with echocardiography
TL;DR: Though performing echocardiography on all patients with atrial fibrillation gave the best quality-adjusted life expectancy, the differences among the five strategies studied were small and sensitivity analysis revealed that the decision was sensitive to many of the variables used in the analysis.
References
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Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
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Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
Journal ArticleDOI
Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
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