Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
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TLDR
The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
Citations
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Journal ArticleDOI
Role of echocardiography in systemic arterial embolism. A review with recommendations.
Henrik Egeblad,Kai Andersen,Jaakko Hartiala,Arne Lindgren,Reijo J. Marttila,Palle Petersen,Anders Roijer,David Russell,Bengt Wranne +8 more
TL;DR: The ability of echocardiography to diagnose sources of embolism and the role of the examination in the prediction of thromboembolism are reviewed and the yield of transthoracic and transoesophageal echOCardiography (TEE) is analysed in patients with suspected emblism and guidelines are proposed.
Journal ArticleDOI
The source of embolism in amaurosis fugax and retinal artery occlusion.
TL;DR: In patients in this age group suffering from either amaurosis fugax or a retinal artery occlusion, a carotid artery duplex scanning should be performed first as this investigation is more likely to provide useful information than an extensive cardiac screening.
Journal ArticleDOI
Deep vein thrombosis. Diagnosis and management.
William F. Baker,Rodger L. Bick +1 more
TL;DR: Use of new approaches for diagnosis and management offers the potential of more prompt and accurate diagnosis, more effective therapy, and a reduction in the incidence of pulmonary thromboembolism.
Journal ArticleDOI
New avenues for anticoagulation in atrial fibrillation.
TL;DR: E efficacy and safety appear to be noninferior, and in some instances superior, to warfarin, however, the new drugs have their downsides, and switching from warfar in is not recommended for all patients.
References
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Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
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Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
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Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
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