Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
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The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
Citations
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Journal ArticleDOI
Optimal Intensity of Warfarin Therapy for Secondary Prevention of Stroke in Patients with Nonvalvular Atrial Fibrillation A Multicenter, Prospective, Randomized Trial
TL;DR: For secondary prevention of stroke in persons with NVAF, especially in old patients, the low-intensity warfarin treatment seems to be safer than the conventional-intensity (INR 2.2 to 3.5) treatment.
Journal ArticleDOI
Warfarin Anticoagulation and Outcomes in Patients With Atrial Fibrillation: A Systematic Review and Metaanalysis
MW Reynolds,Kyle Fahrbach,Ole Hauch,Gail Wygant,Rhonda P. Estok,Catherine Cella,Luba Nalysnyk +6 more
TL;DR: Available evidence indicates that in patients with nonvalvular AF, the risk of ischemic stroke with insufficient warfarin anticoagulation (INR < 2), and therisk of bleeding events with overanticoagulated patients (INr > 3) are significantly higher relative to patients with AF maintained within the recommended INR of 2 to 3.
Journal ArticleDOI
Outcome parameters for trials in atrial fibrillation: recommendations from a consensus conference organized by the German Atrial Fibrillation Competence NETwork and the European Heart Rhythm Association.
Paulus Kirchhof,Angelo Auricchio,Jeroen J. Bax,Harry J.G.M. Crijns,John Camm,Hans-Christoph Diener,Andreas Goette,Gerd Hindricks,Stefan H. Hohnloser,Lukas Kappenberger,Karl Heinz Kuck,Gregory Y.H. Lip,Bertil Olsson,Thomas Meinertz,Silvia G. Priori,Ursula Ravens,Gerhard Steinbeck,Elisabeth Svernhage,Jan G.P. Tijssen,Alphons Vincent,Günter Breithardt +20 more
TL;DR: An expert consensus is described of required outcome parameters in seven relevant outcome domains, namely death, stroke, symptoms and quality of life, rhythm, left ventricular function, cost, and emerging outcome parameters for outcome assessment in AF trials.
Journal ArticleDOI
ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation - executive summary: A report of the American College of Cardiology/American Heart Aassociation task force on practice guidelines and the European society of cardiology committee for practice guidelines (writing committee to revise the 2001 guidelines for the management of patients With atrial fibrillation)Guidelines for the Management of Patients With Atrial Fibrillation)
Jeffrey L. Anderson,Cynthia D. Adams,Elliott M. Antman,Charles R. Bridges,Robert M. Califf,Donald E. Casey,William E. Chavey,Francis M. Fesmire,Judith S. Hochman,Thomas N. Levin,A.M. Lincoff,Eric D. Peterson,Pierre Theroux,Nanette K. Wenger,R. S. Wright,Sidney C. Smith,Alice K. Jacobs,Jonathan L. Halperin,Sharon A. Hunt,Harlan M. Krumholz,Frederick G. Kushner,Bruce W. Lytle,Rick A. Nishimura,Joseph P. Ornato,Richard L. Page,Barbara Riegel +25 more
Journal ArticleDOI
A test of financial incentives to improve warfarin adherence.
Kevin G. Volpp,George Loewenstein,George Loewenstein,Andrea B. Troxel,Andrea B. Troxel,Jalpa A. Doshi,Maureen Price,Mitchell S. Laskin,Stephen E. Kimmel,Stephen E. Kimmel +9 more
TL;DR: A daily lottery-based financial incentive demonstrated the potential for significant improvements in missed doses of warfarin and time out of INR range and further testing should be done of this approach to determine its effectiveness and potential application to both warFarin and other chronic medications.
References
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A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
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Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
Journal ArticleDOI
Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
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