Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
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The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
Citations
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Long-term oral anticoagulation therapy and the risk of hip fracture in patients with previous hemispheric infarction and nonrheumatic atrial fibrillation.
TL;DR: It is shown that long-term warfarin therapy reduces vitamin K and second metacarpal bone mineral density in NRAF patients who had previous hemispheric infarction and that ucOC was significantly related to BMD in treated but not in untreated patients.
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Interventional treatments for stroke prevention in atrial fibrillation with emphasis upon the WATCHMAN device.
TL;DR: For both devices, a reduction in the risk of stroke was documented, and device implantation was shown to be safe and feasible, and another therapeutic option will become available to prevent ischemic strokes.
Journal ArticleDOI
Atrial fibrillation: New management strategies
Sudha M. Pai,Vilma I. Torres +1 more
TL;DR: The main goal of therapy in atrial fibrillation is to restore sinus rhythm, if this is possible, to avoid adverse hemodynamic, electrical, and embolic consequences and to place the patient at a higher risk for developing proarrhythmia.
Journal ArticleDOI
Transesophageal echocardiography-guided approach to cardioversion of atrial fibrillation
TL;DR: Recent studies strongly suggest an alternative mechanism for embolism after cardioversion, ie, atrial stunning with worsened atrial appendage function and enhanced thrombogenesis, as the safest and the most cost-effective way to manage anticoagulation for elective cardioversion.
Journal ArticleDOI
Antithrombotic therapy for stroke prevention in atrial fibrillation.
TL;DR: The existing randomized trial evidence supporting the efficacy of oral vitamin K antagonists (ie, warfarin or aspirin) or aspirin for preventing thromboembolism in AF is reviewed, as well as completed and ongoing studies exploring novel antithrombotic agents.
References
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Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
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Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
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Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
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Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke
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