Journal ArticleDOI
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study.
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The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.About:
This article is published in The Lancet.The article was published on 1989-01-28. It has received 1636 citations till now. The article focuses on the topics: Warfarin & Stroke.read more
Citations
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Journal ArticleDOI
Coumarin therapy in thrombosis.
Graham F. Pineo,Russell D. Hull +1 more
TL;DR: The pharmacology of warfarin sodium, the most commonly used oral anticoagulant in North America, is reviewed and practical aspects of the use of this agent in thrombotic disorder management are discussed.
Journal ArticleDOI
The treatment of atrial fibrillation: pharmacologic and nonpharmacologic strategies.
Journal ArticleDOI
Benefit–risk assessment in a post‐market setting: a case study integrating real‐life experience into benefit–risk methodology
Christine E. Hallgreen,Hendrika A. van den Ham,Shahrul Mt-Isa,Simon Ashworth,Richard C. Hermann,Steve Hobbiger,Davide Luciani,Alain Micaleff,Andrew Thomson,Nan Wang,Tjeerd van Staa,Tjeerd van Staa,Gerald Downey,Ian Hirsch,Kimberley Hockley,Juhaeri Juhaeri,Marilyn Metcalf,Jeremiah Mwangi,Richard Nixon,Ruth Peters,Isabelle Stoeckert,Ed Waddingham,Ioanna Tzoulaki,Deborah Ashby,Lesley Wise +24 more
TL;DR: This case study investigates this specific situation by applying a formal benefit–risk framework to assess the benefit– risk balance of warfarin for primary prevention of patients with atrial fibrillation.
Journal ArticleDOI
Heparin and oral anticoagulants in the treatment of brain ischemia.
Claudia Chaves,Louis R. Caplan +1 more
TL;DR: The mechanism of action of the heparins and warfarin as well as the data regarding their efficacy and complications in patients with ischemic stroke and venous sinus thrombosis are reviewed.
Journal ArticleDOI
Primary Stroke Prevention in Nonvalvular Atrial Fibrillation: Implementing the Clinical Trial Findings
TL;DR: In patients with NVAF, the personal, social, and economic consequences of stroke are often devastating, and additional outcomes research is needed to evaluate the impact of the clinical trial findings and practice guidelines on clinical practice and to develop methods for overcoming barriers to implementation.
References
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Journal ArticleDOI
A multiple testing procedure for clinical trials.
TL;DR: The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same.
Journal ArticleDOI
Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Explanatory and pragmatic attitudes in therapeutical trials
Daniel Schwartz,Joseph Lellouch +1 more
TL;DR: Most therapeutic trials are inadequately formulated from the earliest stages of their conception, and it often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds.
Journal ArticleDOI
Randomised trial of prophylactic daily aspirin in British male doctors
Richard Peto,Richard Gray,Rory Collins,Keith Wheatley,Charles H. Hennekens,K Jamrozik,Charles Warlow,B Hafner,E Thompson,S Norton +9 more
TL;DR: A six year randomised trial was conducted among 5139 apparently healthy male doctors to see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, myocardial infarction, or other vascular conditions.
Journal ArticleDOI
The natural history of lone atrial fibrillation. A population-based study over three decades.
Stephen L. Kopecky,Bernard J. Gersh,Michael D. McGoon,Jack P. Whisnant,David R. Holmes,Duane M. Ilstrup,Robert L. Frye +6 more
TL;DR: It is concluded that lone atrial fibrillation in patients under the age of 60 at diagnosis is associated with a very low risk of stroke, and routine anticoagulation may not be warranted.
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